神经肽FF的生物活性研究进展  

Advances in the Biological Activity of Neuropeptide FF

作　　者：孙瑜隆[1] 马小莉[1] 李迪杰[1] 赵帆[1] 骞爱荣[2] 

机构地区：[1]西北工业大学生命学院 特殊环境生物物理学研究所 空间生物实验模拟技术国防重点学科实验室,陕西西安710072 [2]西北工业大学 生命学院 特殊环境生物物理学研究所 空间生物实验模拟技术国防重点学科实验室,陕西西安710072

出　　处：《现代生物医学进展》2015年第7期1365-1368,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81401553);中国博士后科学基金项目(2014M552492);中央高校基本科研业务费科研资助项目(3102014JKY15010);国家重点基础发展规划项目(973项目)(2011CB710903);陕西省博士后科研资助项目

摘　　要：神经肽FF(neuropeptide FF,NPFF)最初于1985年从牛脑中分离得到,是一种哺乳动物体内普遍存在的八肽。NPFF最早因具有调节阿片镇痛活性而引起关注,而后陆续发现NPFF具有多种生理功能,包括调节体温、心血管、神经内分泌、胃肠运动、摄食、抗炎、免疫调节、以及神经保护等。现在认为NPFF是一种具有激素样活性的神经递质,因此对其生理功能的深入研究有助于理解NPFF在多种生理系统中的作用机制及其潜在多肽药物的研发。本文综述了近年来NPFF生物活性的最新研究进展,结合本实验室已有研究基础,重点介绍了NPFF在神经内分泌、免疫调节、抗炎、神经保护、及信号通路方面的进展,并展望了NPFF类多肽药物今后的发展方向。Neuropeptide FF （NPFF） was originally isolated from bovine brain in 1985. As an octapeptide, NPFF distributes ubiq- uitously among mammals. NPFF was initially recognized as an opioid-modulating peptide for its action in regulating opioid analgesic ac- tivity, however, later studies show that NPFF has important roles in regulating multiple biological processes, such as body temperature, cardiovascular, neuroendocrine, gastrointestinal motility, feeding, anti-inflammation, immunomodulation, and neuroprotection. Currently, NPFF is considered as a hormone-like neurotransmitter. Hence, a comprehensive understanding on NPFF bioactivity will be helpful for not only the mechanism of NPFF in multiple physical roles but also the potential peptide drug development. In this paper, the latest ad- vances in NPFF bioactivity are reviewed, especially its fimctions in neuroendocrine, immune regulation, anti-inflammatory, and neuro- protective. Moreover, the research trends for the future are prospected.

关 键 词：神经肽 NPFF NPFF受体 RF9 免疫调节 

分 类 号：R392[医药卫生—免疫学] R335[医药卫生—基础医学]