中药防治假体周围骨溶解的研究进展  

Research Progress of Chinese Medicine to Prevent Periprosthetic Osteolysis

作　　者：金亮[1] 孙闯[1] 于大淼[1] 徐英 郑未来 廉永云[1] 

机构地区：[1]哈尔滨医科大学附属第四医院骨五科,黑龙江哈尔滨150001 [2]齐齐哈尔市中医医院,黑龙江齐齐哈尔161000

出　　处：《现代生物医学进展》2015年第7期1380-1382,共3页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科学技术研究项目(GC09C412-3)

摘　　要：现如今人工关节置换术越来越多的应用于重建关节功能改善关节疾病患者的生活质量,但是术后并发症严重影响了手术的效果,人工假体周围骨溶解及假体无菌性松动又是人工关节置换术后失败的主要原因之一,所以如何预防以及发病后如何去治疗成为现今关节医生面临的重要课题。OPG/RANKL/RANK系统,炎性因子的产生,破骨细胞、成骨细胞这些都是影响人工假体术后产生无菌性松动,和引发假体周围骨溶解的重要因素,有效药物的干预治疗成为现如今关节置换术后以及围手术期的热门话题,中药因其副作用小,疗效独特,及深入的研究逐渐受到广大医生的注意,因此中药在治疗人工假体松动及骨溶解方面也得到了重大突破,本文从中医肾藏精,精生髓,髓能养骨理论着手总结中药作用于OPG/RANKL/RANK系统,抑制炎性因子、破骨细胞及促进成骨细胞增殖的研究现状。Now arthroplasty more and more used in the reconstruction of joint function to improve the quality of life in patients with joint disease, but serious postoperative complications affecting the effect of the surgery, artificial periprosthetic osteolysis and aseptic loosening one of the main reasons for artificial joint replacement surgery failed, so how to prevent and how to go after the onset of treat- ment has become an important issue that the joint doctors face. OPG/RANKL/RANK system, inflammatory cytokine production, osteo- clasts, and osteoblasts are affecting the prosthesis postoperative produce aseptic loosening, and raises an important factor in periprosthetie osteolysis, effective drug intervention treatment has become a hot topic now in joint replacement surgery and perioperative medicine be- cause of its side effects, unique effect, and in-depth research gradually by the attention of the majority of doctors, Chinese medicine in the treatment of prosthesis loosening and osteolysis has also been a major breakthrough. From the Chinese kidney storing the essence, the essence bringing forth marrow, and the theory that marrow can raise bone, this review summarizes the research status of the traditional Chinese medicine acting on the OPG/RANKL/RANK system, inhibition of inflammatory factors, osteoclasts and promote bone cell pro- liferation research.

关 键 词：中药 OPG RANKL 成骨细胞 破骨细胞 

分 类 号：R285.6[医药卫生—中药学] R68[医药卫生—中医学]