Occludin蛋白与细胞间紧密连接关系及其临床意义  

The Relationship between Protein Occludin and Tight Junctions and its Clinical Significance

作　　者：邢晓辉[1] 李力仙[1] 郭天林[1] 梁里昂 

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第8期1553-1555,1405,共4页Progress in Modern Biomedicine

基　　金：黑龙江省留学基金项目(LC2011C16)

摘　　要：细胞间紧密连接(tight junctions)广泛存在于上皮细胞及内皮细胞之间,其作用是保持细胞间结构的完整性,确保其功能的正常发挥,紧密连接上有很多种蛋白,occludin蛋白是其中主要蛋白之一,occludin蛋白的结构发生变化会导致紧密连接结构及功能的改变,而紧密连接结构与功能的紊乱是很多临床疾病共同的病理生理学特点,如肿瘤、中风及炎症性肺疾病。Occludin蛋白的结构及功能的改变受很多机制的调控,本文主要对occludin蛋白的结构、功能、调控机制及其与紧密连接之间的关系进行叙述。There are widely existents of tight junctions between epithelial cell and endothelial cell. The function of tight junctions is to maintain the integrity of the structure between epithelial cells and endothelial cells and ensure the normal function. Protein occludin is one of the important proteins in tight junctions. The changes of the structure of the occludin result in the disorder of structure and function of tight junctions. Disorders of function and structure of tight junctions have relationship between many clinical diseases,such as stroke, tumor and inflammatory lung disease. The changes of structure and function of Protein occludin are regulated by many mechanisms. In this paper, the structure and function of protein occludin and its relationship with tight junctions were described.

关 键 词：细胞间紧密连接 OCCLUDIN ZO-1 

分 类 号：R591[医药卫生—内科学] Q753[医药卫生—临床医学]