MMP-2与Ⅰ型胶原关系的研究进展  

MMP-2 and Collagen Type Ⅰ

作　　者：田甜[1] 朱煌[1] 王洁[1] 蔡晓静[1] 牛宗镇[1] 

机构地区：[1]上海交通大学医学院附属新华医院眼科,上海200092

出　　处：《现代生物医学进展》2015年第9期1775-1777,1759,共4页Progress in Modern Biomedicine

基　　金：上海市科委医学引导资助项目(10411966200);上海市卫生局中医药科研基金(2014JP015A)

摘　　要：MMP-2与I型胶原分别为基质金属蛋白酶家族的重要成员和细胞外基质的主要成分,近年来研究发现,MMP-2与Ⅰ型胶原的表达与调控在多种与胶原代谢有关的疾病中起着重要作用。通过增强或抑制MMP-2来调控I型胶原,进而防止疾病的发生发展已成为很多疾病的研究热点。对MMP-2与Ⅰ型胶原关系更新的认识也引起了越来越多的关注,必然带动对MMP-2与Ⅰ型胶原更深层次的研究,本文就近年来有关MMP-2与Ⅰ型胶原的研究进展做一综述,为多种胶原代谢疾病发病机理与防治的探究提供新的思路和理论依据。MMP-2 is an important member of the matrix metalloproteinase family. Type I collagen is the major component of the extracellular matrix. The expression and regulation between MMP-2 and type Ⅰ collagen play an important role in a variety of diseases associated with collagen metabolism. To regulate type I collagen by enhancing or inhibiting the MMP-2 has become a hotspot in many researches of diseases. Updated knowledge of MMP-2 and collagen I also attracted more and more attention, inevitably leading to deeper research on MMP-2 and type I collagen. In this paper researches about MMP-2 and type Ⅰ collagen in recent years were reviewed to provide new ideas and theoretical basis for the researches on the pathogenesis and prevention of metabolic diseases.

关 键 词：基质金属蛋白酶-2 Ⅰ型胶原 近视 肿瘤 纤维化 

分 类 号：R593.2[医药卫生—内科学]