左旋卡尼汀联合环磷腺苷葡胺治疗慢性充血性心力衰竭  

L-carnitine Combined with Meglumine Cyclic Adenosine Monophosphate in Chronic Congestive Heart Failure

作　　者：王晓勇 燕成英 孔祥明[2] 黄学莲 吴静 胡佳良 胡新华[3] 

机构地区：[1]青海省西宁市第一人民医院,青海西宁810000 [2]青海大学附属医院,青海西宁810001 [3]中国医科大学,辽宁沈阳110032

出　　处：《现代生物医学进展》2015年第10期1895-1898,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30672048)

摘　　要：目的:探究左旋卡尼汀联合环磷腺苷葡胺治疗慢性充血性心力衰竭(chronic congestive heart failure,CHF)的临床疗效。方法:选取我院心内科CHF患者58例,随机分为对照组28例与实验组30例,其中对照组28例,予地高辛、氢氯噻嗪、环磷腺苷葡胺常规治疗;实验组30例,在常规治疗的基础上加用左旋卡尼汀治疗。观察两组患者治疗前后心功能分级(NYHA)、6 min步行距离、左心室射血分数(LVEF)及左心室舒张末容积(LVEDD)等。结果:与对照组比较,实验组患者治疗后心率和NYHA心功能分级明显改善,6 min步行实验明显提高,患者LVEDD、LVEF明显改善,差异具有统计学意义(P<0.05);两组患者接受相应治疗后均未出现任何不良反应(P>0.05)。结论:左旋卡尼汀联合环磷腺苷葡胺能够明显改善慢性充血性心力衰竭,对临床具有指导意义,值得临床推广。Objective： To explore clinical efficacy of L-carnitine combined with meglumine cyclic adenosine monophosphate in the treatment of chronic congestive heart failure（CHS）. Methods： 58 cases of CHF were randomly divided into control group of 28 patients and experimental group of 30 cases. The patients of the control group were given conventional treatment including digoxin,hydrochlorothiazide, and cyclic adenosine monophosphate meglumine; while the experimental group was treated with L-carnitine on the basis of conventional therapy. The NYHA functional grade, 6min walking distance, left ventricular ejection fraction（LVEF） and left ventricular end-diastolic volume（LVEDD） were compared between the two groups before and after treatment. Results： Compared with the control group, the heart rate and NYHA functional grade, the six-minutes＇ walk test, the LVEDD and LVEF in the experimental group improved significantly（P0.05）. There was no adverse reaction in the two groups（P0.05）. Conclusions： L-carnitine combined with meglumine cyclic adenosine monophosphate can significantly improve chronic congestive heart failure.

关 键 词：左旋卡尼汀 环磷腺苷葡胺 慢性充血性心力衰竭 

分 类 号：R541.61[医药卫生—心血管疾病]