少突胶质前体细胞治疗脊髓损伤的研究进展  

Progress in Treatment Spinal Cord Injury with Oligodendrocyte Progenitor Cells

作　　者：王凤昌[1] 栾佐[1] 杨印祥[1] 何志旭[1] 朱中康 

机构地区：[1]北京海军总医院,北京100048

出　　处：《现代生物医学进展》2015年第10期1950-1953,共4页Progress in Modern Biomedicine

基　　金：科技部国际合作专项基金项目(2012DFA30880)

摘　　要：脊髓损伤(spinal cord injury,SCI)是一种严重危害人类生命健康的疾病,其发病率呈现逐年上升的趋势,并且治疗较为困难。研究发现脊髓损伤后少突胶质细胞大量死亡,引发脱髓鞘病变,这可能是其难以治疗的原因之一。少突胶质前体细胞(OPCs)为少突胶质细胞的祖细胞,后者是中枢神经系统的成髓鞘细胞。OPCs来源于胚胎发育早期神经管腹侧神经上皮细胞,随着神经管的发育,OPCs逐渐增殖、迁移并分化为成熟OL,参与中枢神经系统轴突髓鞘的形成。随着对OPCs的不断深入研究,发现OPCs移植对SCI有较好的疗效,这可能为SCI患者开辟一条新的治疗途径。本文就OPCs治疗SCI的动物实验研究结果做一综述。Spinal cord injury（SCI） is a devastating condition producing great personal and societal costs and for which there is no effective treatment available. SCI cause the massive death of oligodendrocyte, which may be responsible for the hard-to-treat of SCI.Oligodendrocyte progenitor cells（OPCs） are the precursor cells of oligodendrocyte, the myelination cells in the central nervous system.OPCs, which are originated from the ventral neural tube-derived neuroepithelial cells, will proliferate, migrate and differentiate into mature oligodendrocyte during neural tube development. Several studies showed that OPCs transplantation could promote functional recovery after SCI. This review is to summarize the experiments where OPCs transplantation produced successful functional outcome in animal models of SCI.

关 键 词：少突胶质前体细胞 脊髓损伤 治疗 

分 类 号：R651.2[医药卫生—外科学]