心肌坏死标志物联合检测对急性心肌梗死早期诊断及鉴别的价值  被引量:19

Significance of Combined Detection of Myocardial Necrosis Markers for Early Diagnosis of Acute Myocardial Infarction

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作  者:杨忠路[1] 王辉山[1] 刘涛[1] 张仁腾[1] 姜辉[1] 

机构地区:[1]沈阳军区总医院心血管外科,辽宁沈阳110016

出  处:《现代生物医学进展》2015年第11期2086-2088,共3页Progress in Modern Biomedicine

基  金:辽宁省科学技术计划项目(2013225089)

摘  要:目的:探讨心肌坏死标志物联合检测在急性心肌梗死早期诊断及鉴别中的意义。方法:选取2010年12月至2013年5月我院收治的90例患者,45例确诊急性心肌梗死患者为观察组,其余45例非急性心肌梗死患者为对照组。分别采集两组患者静脉血4 m L用于检验。采用免疫抑制法测定患者血清中肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)含量,采用电化学发光法检测肌钙蛋白I(c Tn I)和肌红蛋白(MYO)含量。观察并比较不同时间点两组患者血清中CK、CK-MB、c TnⅠ及MYO含量的变化情况。结果:与对照组比较,观察组的血清CK、CK-MB、c TnⅠ及MYO的含量明显升高,其中CK及MYO升高最为显著,差异具有统计学意义(P〈0.05)。CK、CK-MB在发病3~6 h后快速升高,24 h达高峰;c TnⅠ前24 h与CK-MB同步,但维持时间较长;MYO在发病后1~2 h发生异常,12 h达峰值(P〈0.05)。结论:心肌坏死标志物联合检测可提高急性心肌梗死的检出率,有助于疾病的及时发现、诊断和治疗。Objective: To investigate the significance of detection of combined myocardial necrosis markers in the early diagnosis and differentiation of acute myocardial infarction. Methods: 90 patients who were treated in our hospital from December 2010 to May2013 were enrolled. Among the 90 patients, 45 with the acute myocardial infarction were selected as the observation group, while another 45 patients without acute myocardial infarction were named the control group. Immunosuppression was used to determine the concentrations of creatine kinase(CK) and CK-MB, and electrochemiluminescence was used for the detection of troponin Ⅰ(c TnⅠ) and myoglobin(MYO). The concentrations of CK, CK-MB, c TnⅠ and MYO at different time in the serum of patients were recorded and compared between the two groups. Results: Compared with the control group, CK, CK-MB, c TnⅠ and MYO levels in the observation group increased significantly, and the CK and MYO obviously increased(P0.05); CK and CK-MB levels increased rapidly 3-6 h, and peaked at 24 h; c Tn Ⅰ level was synchronous with CK-MB in 24 hours and maintained longer in the blood; MYO level occurred abnormality at 1 2 h after the onset and reached the peak in 12 h, which was significantly earlier than the other three indicators(P〈0.05).Conclusion: Combined myocardial necrosis markers can improve the detection rate of acute myocardial infarction and contribute to timely detection, diagnosis and treatment of the disease.

关 键 词:急性心肌梗死 心肌坏死标志物 联合检测 

分 类 号:R542.22[医药卫生—心血管疾病]

 

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