JAK/STAT信号通路调节机制的研究进展  

Research Progress of Regulating Mechanism on JAK/STAT Signaling Pathway

作　　者：薛翔[1] 刘红梅[1] 邵旦兵[1] 唐文杰[1] 聂时南[1] 

机构地区：[1]南京军区南京总医院急救医学科,江苏南京210002

出　　处：《现代生物医学进展》2015年第11期2161-2165,共5页Progress in Modern Biomedicine

基　　金：解放军南京军区重大专项课题(12Z32)

摘　　要：Janus激酶/信号转导与转录激活子(The Janus kinase/signal transducer and activator of tran-scriptions,JAK/STAT)信号通路是是众多细胞因子信号转导的共同途径,广泛参与细胞增殖、分化、凋亡以及炎症等过程,可以通过负调节因子、与其他信号通路相互作用、STATs共价修饰等多种途径进行调节。JAK/STAT通路的激活促进各种疾病的发生发展,包括各种实体肿瘤、淋巴瘤、白血病以及炎症性疾病等疾病,针对JAK/STAT信号通路的靶向治疗是目前的热点,本文主要就JAK/STAT信号通路调节机制及针对此通路的靶向治疗的相关进展做一综述。The Janus kinase/signal transducer and activator of transcriptions Signaling pathway is the important signal transduction pathways which is widely involved in cell proliferation, differentiation, apoptosis, and inflammation and other processes. It can be regulated by negative regulatory factors, interaction with other signaling pathways, STATs covalent modification and other ways.Activation of JAK / STAT pathway promotes the development of various diseases including various solid tumors, lymphoma, leukemia and inflammatory diseases and other diseases. Currently, targeting therapy for the JAK / STAT signaling pathway is a hot. This article focuses on the relevant developments of JAK / STAT signaling pathway regulating mechanisms and targeting therapy for the JAK /STAT signaling pathway.

关 键 词：JAK/STAT信号通路 调节机制 细胞因子信号转导抑制蛋白 蛋白酪氨酸磷酸酶 靶向治疗 

分 类 号：Q756[生物学—分子生物学] R34[医药卫生—基础医学]