TGF-β2与妊娠期高血压疾病  

Transforming Gowth Factor- beta 2 and Pregnancy Induced Hypertension

作　　者：杨慧春[1] 蔡丽瑛[1] 杨扬[1] 宁艳[1] 孙敬霞[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第11期2169-2172,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅科研课题(2009-091)

摘　　要：妊娠期间母胎界面存在着复杂的免疫调控关系,蜕膜及绒毛作为母体及胎儿的直接接触面,是发生免疫反应的重要部位。多种细胞因子如转化生长因子-β、肿瘤坏死因子-α及血管内皮细胞等具有营养细胞、调控滋养细胞侵入、免疫抑制、防止母胎排斥等多种功能,他们在正常妊娠的维持中起着重要的作用。目前转化生长因子-β2的作用已越来越受重视,本文将从转化生长因子-β2与妊娠期高血压疾病存在的关系作如下综述。There are complicated immunoregulations in maternal-fetal interface. As a direct maternal-fetal interface, decidua and villi are important positions for immunoreaction. Many kinds of cytokines such as transforming growth factor-beta, tumor necrosis factor-α and vascular endothelial growth factor, are all important trophoblast cell regulators which excert many roles： nutrition, regulating invasion of trophoblasts, immnosuppression, preventing the fetus from maternal rejection. They play important roles in maintaining normal pregnancy. At present, they pay more attention to the role of transforming growth factor-bate 2. This article will do the review as follows on the relationship between transforming growth factor beta 2 and Pregnancy Induced Hypertension.

关 键 词：转化生长因子-Β2 滋养细胞 肿瘤坏死因子-Α Γ-干扰素 妊娠期高血压疾病 

分 类 号：R714.24[医药卫生—妇产科学]