卵巢低反应患者体外受精方式的临床效果分析  

Clinical analysis of in vitro fertilization among infertility patients with poor ovarian response

作　　者：孔蕊[1] 田莉[1] 

机构地区：[1]北京大学人民医院生殖中心,100044

出　　处：《中国计划生育学杂志》2015年第4期242-245,共4页Chinese Journal of Family Planning

摘　　要：目的：探讨不孕症患者实施体外受精-胚胎移植（IVF-ET）治疗中卵巢低反应（POR）者IVF方式对妊娠结局的影响。方法：回顾性分析非严重男性因素不孕患者行IVF-ET治疗POR的246个周期临床资料,比较常规行IVF（IVF组）和卵胞浆内单精子注射（ICSI组）治疗者的正常受精率、周期取消率、优质胚胎率、临床妊娠率和早期流产率。根据女方年龄分为〉35～40岁组和〉40岁组,分别比较两组行IVF和ICSI治疗的受精率、周期取消率、优质胚胎率、临床妊娠率。根据获卵1、2、3枚分组,比较各组内不同受精方式者上述各项指标。结果：整体比较及不同女方年龄组、不同获卵数组中接受IVF与ICSI治疗的正常受精率、周期取消率、优质胚胎率、临床妊娠率和早期流产率均无统计学差异（P〉0.05）。结论：ICSI不能改善非严重男性因素不孕POR者的正常受精率和妊娠结局,女方高龄、取卵数少均不是ICSI的适应证。Objective：To compare the efficacy of intracytoplasmic sperm injection（ICSI）and conventional in vitrofertilization（IVF）among non-severe-male infertility women with poor ovarian response.Methods：A total of 246IVF/ICSI-embryo transfer（ET）cycles of non-severe-male infertility women with poor ovarian response were divided into IVF group and ICSI group.The fertilization rate,cycle cancellation rate,high quality embryo rate,clinical pregnancy rate and early abortion rate were retrospectively analyzed between two groups.Then 246IVF/ICSI-ET cycles were divided into A group（35to 40 years old）and B group（40years old）according to the age of women.The fertilization rate,cycle cancellation rate,high quality embryo rate and clinical pregnancy rate were retrospectively analyzed between two groups.Finally indicators mentioned above were respectively compared between IVF and ICSI group according to the number of oocytes retrieved（one to three）.Results：There were no significant differences in the fertilization rate,cycle cancellation rate,high quality embryo rate,clinical pregnancy rate and early abortion rate when compared in three ways（Pall0.05）.Conclusion：ICSI can not improve the fertilization results and clinical outcomes in non-severemale infertility women with poor ovarian response.In particular,the old age and low number of oocytes retrieved are not indications of ICSI.

关 键 词：体外受精 卵泡浆内单精子注射 卵巢低反应 受精方式 辅助生殖技术 

分 类 号：R714.8[医药卫生—妇产科学]