不同糖耐量绝经后女性氧化低密度脂蛋白水平的比较及相关因素的研究  

Comparison of oxidized low-density lipoprotein levels among postmenopausal women with different glucose tolerance and study on the related factors

作　　者：陈海兰[1] 高宇[1] 王英南[1] 刘晓燕[1] 冯增斌[1] 葛晓春[1] 

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《中国妇幼保健》2015年第11期1672-1674,共3页Maternal and Child Health Care of China

基　　金：河北省卫生厅科研基金项目〔20130022〕

摘　　要：目的:探讨不同糖耐量状态下绝经后女性血清氧化低密度脂蛋白(ox-LDL)水平及其相关影响因素。方法:选取120例绝经后女性,其中糖耐量正常(NGT组)40例、糖耐量受损(IGR组)40例及2型糖尿病(T2DM组)40例。采用ELISA检测血清中ox-LDL水平,分析比较各组ox-LDL的水平及其与血脂、血糖(FBG)、收缩压(SBP),舒张压(DBP)、同型半胱氨酸(Hcy)的相关性。结果:与NGT组比,T2DM组及IGR组均具有较高的ox-LDL、LDL-C、SBP、DBP水平(P<0.05),且T2DM组血Hcy明显高于NGT组(P<0.01)。与IGR组相比,T2DM组具有较高的ox-LDL、TG、TCH、LDL-C、FBG及低HDL-C水平(P<0.05),两组间的SBP、DBP、Hcy差异无统计学意义(P>0.05)。多元线性回归分析ox-LDL与Hcy、LDL-C、FBG、SBP呈正相关,与HDL-C呈负相关(P<0.05),各相关指标对ox-LDL水平影响的标准化回归系数(β)分别为0.394(FBG)、0.213(Hcy)、0.177(SBP)、-0.139(HDL-C)和0.125(LDL-C)(P<0.05)。结论:随着糖耐量异常程度的加重,血清ox-LDL水平也呈升高趋势,而且高血糖、高Hcy、高血压及血脂紊乱是ox-LDL的独立危险因素。Objective： To explore the levels of serum oxidized low- density lipoprotein（ ox- LDL） among postmenopausal women with different glucose tolerance and the related influencing factors. Methods： A total of 120 postmenopausal women were selected and divided into normal glucose tolerance（ NGT） group（ 40 women）,impaired glucose tolerance（ IGT） group（ 40 women）,and type 2 diabetes mellitus（ T2DM） group（ 40 women）. ELISA was used to detect the levels of serum ox- LDL; the correlations between serum ox- LDL levels and blood lipid,fasting blood glucose（ FBG）,systolic blood pressure（ SBP）,diastolic blood pressure（ DBP）,homocysteine（ Hcy）in the three groups were analyzed and compared. Results： Compared with NGT group,the levels of ox- LDL,LDL- C,SBP,and DBP were statistically significantly higher than those in T2 DM group and IGR group（ P 〈0. 05）,the level of Hcy in T2 DM group was statistically significantly higher than that in NGT group（ P 〈0. 01）. Compared with IGT group,the levels of ox- LDL,TG,TCH,LDL- C,and FBG were higher and the level of HDL- C was lower in T2 DM group（ P 〈0. 05）,there was no statistically significant difference in SBP,DBP,and Hcy between IGT group and T2 DM group（ P 〉0. 05）. Multivariate linear regression analysis showed that ox- LDL was positively correlated with Hcy,LDL- C,FBG,SBP; ox- LDL was negatively correlated with HDL- C（ P 〈0. 05）,the standardized regression coefficients（ β） of the effects of related indexes on ox- LDL level were 0. 394（ FBG）,0. 213（ Hcy）,0. 177（ SBP）,- 0. 139（ HDL- C）,and 0. 125（ LDL- C）,respectively（ P 〈0. 05）. Conclusion： With the aggravation of abnormal glucose tolerance,serum ox- LDL level shows an increasing trend,hyperglycaemia,hyperhomocysteinemia,hypertension,and dyslipidemia are independent risk factors of ox-LDL.

关 键 词：2型糖尿病 糖调节受损 绝经 氧化低密度脂蛋白 同型半胱氨酸 

分 类 号：R711.75[医药卫生—妇产科学]