血清视黄醇结合蛋白和C反应蛋白对妊娠期糖尿病的早期预测价值  

Predictive value of serum retinol conjugated protein and C-reactive protein for early gestational diabetes mellitus

作　　者：袁小松[1] 周慧娜[1] 魏梓雯[1] 蒋丽霞[1] 张一鸣[1] 

机构地区：[1]南京医科大学附属常州市妇幼保健院检验科,江苏常州213003

出　　处：《中国妇幼保健》2015年第11期1771-1773,共3页Maternal and Child Health Care of China

基　　金：常州市科技规划项目〔CJ20130041〕

摘　　要：目的：探讨妊娠妇女血清视黄醇结合蛋白和C反应蛋白早期预测妊娠期糖尿病的价值。方法：采用病例对照研究,检测并比较88例妊娠期糖尿病及88例正常妊娠妇女孕16-20周血清视黄醇结合蛋白和C反应蛋白浓度水平。结果：妊娠期糖尿病组孕妇血清视黄醇结合蛋白和C反应蛋白浓度均高于对照组,差异有统计学意义（P〈0.05）,血清视黄醇结合蛋白和C反应蛋白水平呈正相关（P〈0.05）。血清视黄醇结合蛋白≥30.45 mg/L时预测妊娠期糖尿病的敏感性为63.6%,特异性为75.0%;血清C反应蛋白≥3.25 mg/L时预测妊娠期糖尿病的敏感性为56.8%,特异性为68.2%。结论：孕16-20周孕妇血清视黄醇结合蛋白水平对于妊娠期糖尿病的预测价值高于血清C反应蛋白。Objective： To explore the predictive value of serum retinol conjugated protein and C- reactive protein（ CRP） for early gestational diabetes mellitus（ GDM）. Methods： A case- control study was performed to detect and compare the levels of serum retinol conjugated protein and CRP between 88 patients with GDM（ GDM group） and 88 normal pregnant women（ control group） during 16- 20 gestational weeks. Results： The levels of serum retinol conjugated protein and CRP in GDM group were statistically significantly higher than those in control group（ P 〈0. 05）,serum retinol conjugated protein level was positively correlated with CRP level（ P 〈0. 05）. When the level of serum retinol conjugated protein≥30. 45 mg / L,the sensitivity and specificity for predicting GDM were 63. 6% and 75. 0%,respectively; when the level of CRP≥3. 25 mg / L,the sensitivity and specificity for predicting GDM were 56. 8% and 68. 2%,respectively. Conclusion： The predictive value of serum retinol conjugated protein for GDM is higher than that of serum CRP among the pregnant women during 16- 20 gestational weeks.

关 键 词：视黄醇结合蛋白 C反应蛋白 妊娠期糖尿病 

分 类 号：R714.256[医药卫生—妇产科学]