中国涿州地区社区居民血管功能状况及其相关因素分析  

Evaluation of Arterial Stiffness and Related Risk Factors in Community Residents of Zhuozhou District in China

作　　者：陈富荣[1] 谢斐[1] 杜立平[1] 张健[1] 王晓辉[1] 吕秀华[1] 金怡[1] 余琼斌[1] 刘金波[2] 王宏宇[2] 

机构地区：[1]中国石油集团东方地球物理勘探有限责任公司中心医院,涿州072751 [2]北京大学首钢医院血管医学中心,北京100144

出　　处：《中国医药导刊》2015年第3期217-218,221,共3页Chinese Journal of Medicinal Guide

基　　金：北京市卫生局首都卫生发展科研专项"北京地区血管事件高危人群中血管病变早期检测系统的建立及其预测价值研究"(编号:首发2011-4026-02);北京大学首钢医院院内基金"高血压患者血压变异性与高同型半胱氨酸血症之间的相关性研究"(编号:2012Y04);首钢总公司科研项目"首钢干部群体血管早期病变评估及其健康管理随访研究"(编号:2013科管20-1);首钢院内2014年度医院临床重点项目建设课题"血管病变早期检测系统的建立及其预测价值(编号:2014-院-临床-02);北京大学医学部种子基金"脉搏波速度无创检测新技术"(编号:BMU20140395);东方地球物理公司矿区服务事业部科研项目"东方公司社区居民血管早期病变评估及其健康管理随访研究"(编号:KQ2014-10);北京大学首钢医院院内基金"II型糖尿病患者同型半胱氨酸水平与亚甲基四氢叶酸还原酶基因多态性的研究"(编号:SGYY201406)

摘　　要：目的:探讨中国涿州地区社区居民血管功能状况及其相关因素分析。方法:入选社区居民444人,根据心踝血管指数(CAVI)水平分为两组:CAVI<9组(n=331),CAVI≥9组(n=113)。CAVI由Vasera VS-1500动脉功能检测装置测定。结果:入选人群高血压、冠心病(CHD)、糖尿病(DM)发病率为48%、18%、20%。CAVI≥9组年龄、收缩压(SBP)、脉压(PP)、血糖(FBG)水平均显著高于对照组(P<0.05)。相关性分析提示总体人群中CAVI与年龄、FBG、SBP、PP呈显著正相关性(r=0.640,0.150,0.298,0.379,P均<0.05),而与体质指数(BMI)呈显著负相关性(r=-0.249,P<0.05),多元回归分析提示CAVI与年龄、SBP、BMI、FBG有关(β=0.492,P<0.001;β=0.238,P<0.001;β=-0.261,P<0.001;β=0.159,P=0.005)。结论:涿州地区居民高血压、CHD、DM的发病率明显升高,CAVI≥9组人群年龄、SBP、PP、FBG水平均显著高于对照组。Objective： To investigate the possible risk factors involving arterial function in community residents of Zhuozhou district in China.Methods： 444 subjects from community residents were enrolled into our study. They were divided into two groups：cardio-ankle vascular index （CAVI）〈9（n=331）group and CAVI≥9（n=113） group.Results：The incidences of hypertension, coronary heart disease and diabetes mellitus were significantly higher in CAVI≥9 group. The levels of age, systolic blood pressure （SBP）, pulse pressure （PP）, glucose were significantly higher in CAVI≥9 group than in control group （P〈0.05）. CAVI was positively correlated with age, glucose, SBP and PP in the entire study group（r=0.640,0.150,0.298,0.379,Pall〈0.05）.There was negative correlation between CAVI and body mass index （BMI） in the entire group（r= -0.249,P〈0.05）. Multivariate analysis showed that age, SBP, BMI and glucose were significant independent associating factors of CAVI in all subjects（β=0.492,P〈0.001; β=0.238,P〈0.001; β= -0.261,P〈0.001; β=0.159, P=0.005）.Conclusions： The incidences of hypertension, coronary heart disease and diabetes mellitus were high in community residents of Zhuozhou district. The levels of age, SBP, PP, glucose were significantly higher in CAVI≥9 group.

关 键 词：动脉硬化 心踝血管指数 

分 类 号：R543.5[医药卫生—心血管疾病]