功能化修饰的超支化聚缩水甘油醚在药物载体领域的应用  

Functionally Modified Hyperbranched Polyglycerols for Drug Delivery

作　　者：张奕[1] 巫凌波 胡倩[1] 陈宝欣 吴柏杨 薛巍[1] 

机构地区：[1]暨南大学生物医学工程系广东省高校生物材料重点实验室,广州510632

出　　处：《应用化学》2015年第4期367-378,共12页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金项目(81101151,31271019)~~

摘　　要：随着纳米医学的发展,具有控制释放药物和生物活性分子、靶向刺激响应生理环境的聚合物纳米载体成为该领域活跃而具潜力的研究方向。超支化聚缩水甘油醚因其特定的三维结构、良好的亲水性、生物相容性和可修饰性而引起生物材料界的广泛关注。而经功能化修饰的超支化聚缩水甘油醚还可自组装成胶束、囊泡等药物载体或共价偶联成大分子前药。本文从超支化聚缩水甘油醚的疏水两亲修饰、环境敏感性功能化和超分子组装体改性三方面综述了功能化修饰的超支化聚缩水甘油醚在药物载体领域的研究进展。并系统归纳了超支化聚缩水甘油醚两亲功能化、环境敏感功能化的分子设计策略。另外,对基于环糊精主客体作用的超支化超分子聚缩水甘油醚共聚物的组装行为进行了简述。Polymeric nanocarriers with controllable drug realease and stimuli-responsive to targeted biological conditions are an advancing and potential carrier candidate for nanomedicines. Hyperbranched polyglycerols （HPG） spur the interest of the biomaterial community due to their well-defined three-dimensional structures, good solubility, high biocompatiblity and multiple attachment sites for modification. Functionally modified HPG derivatives are able to self-assemble into a variety of drug carriers such as micelles and vesicles. Herein, we present the current progress on functional modified HPG for drug delivery with particular focus on amphiphilic modification, stimuli-responsive functionalization, as well as supramolecular self-assembly. Molecular design strategy for HPG modification with amphiphilic and stimuli responsive functionalization is systematically summarized. Furthermore, the assembly behavior of hyperbranched supramolecular polyglycerol copolymers based on cyclodextrin host-guest interactions is also mentioned.

关 键 词：超支化聚缩水甘油醚 药物载体 两亲性修饰 环境敏感 超分子自组装 

分 类 号：O632[理学—高分子化学] TB324[理学—化学]