有机催化蒽酮与β-硝基烯烃的不对称Michael加成反应  

Organocatalytic Asymmetric Michael Addition of Anthrone with β-Nitroolefins

作　　者：张天一[1] 年文霞 金瑛[1] 

机构地区：[1]吉林医药学院药物化学教研室,吉林吉林132013

出　　处：《应用化学》2015年第4期422-427,共6页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(21102055);吉林省自然科学基金(201015237)资助项目~~

摘　　要：将金鸡纳生物碱衍生物用于催化蒽酮和β-硝基芳基乙烯的不对称Michael加成反应。考察了溶剂、温度及催化剂用量对反应催化性能的影响。结果表明,最佳条件为5%（摩尔分数）催化剂1b、甲苯为溶剂、0℃反应,得到了91%~99%的化学产率和最高达95%ee的对映体选择性。Cinchona alkaloid derivatives as organocatalysts were applied in asymmetric Michael addition reaction of anthrone with various trans-β-nitroolefins. Solvent, temperature and catalyst loading were screened. The optimized conditions are using toluene as the solvent with a 5% （molar fraction） loading of catalyst lb at room temperature. The products are obtained in 91% -99% yield with up to 95% ee.

关 键 词：金鸡纳生物碱衍生物 有机催化 不对称MICHAEL加成反应 蒽酮 β-硝基烯烃 

分 类 号：O621.3[理学—有机化学]