直接肾素阻滞剂Aliskiren预防早产儿视网膜病变  

Direct renin inhibitors Aliskiren preventing retinopathy of prematurity

作　　者：马誉铷 刘鹤南[1] 底煜[1] 陈晓隆[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,辽宁省沈阳市110004

出　　处：《眼科新进展》2015年第4期393-396,共4页Recent Advances in Ophthalmology

基　　金：辽宁省科技厅基金资助(编号:2013225049);沈阳市科技专项基金资助(编号:F13-220-9-37)~~

摘　　要：肾素作为肾素-血管紧张素系统(renin-angiotensin system,RAS)中上游生长因子,对RAS链起着特异性限速的作用。在早产儿视网膜病变等缺血性视网膜病变中,RAS上调,视网膜RAS被激活,刺激血管内皮生长因子等上调,导致血管渗漏、血管内皮细胞增生和新生血管形成等血管病理性改变。直接肾素抑制剂Aliskiren作为阻断RAS的新途径,在防止和减弱病理性血管生成的过程中发挥了明显作用。Renin,a upstream growth factor of renin angiotensin system（ RAS）,has the effects of specific-speed-limiting on the RAS chain. In many ischemic retinopathy cases such as retinopathy of prematurity（ ROP）,as the RAS increases,the RAS of retina is activated,which might stimulate the rise of vascular endothelial growth factor（ VEGF）,result in vascular pathological changes,led to the leakage of blood vessels and the proliferation of vascular endothelial cell and neovascularization. Being adopted as a new way of blocking the RAS,Aliskiren plays a distinctive role in the process of preventing and abating pathological angiogenesis. The application of Aliskiren is becoming a promising approach for the prevention and treatment of ROP.

关 键 词：肾素-血管紧张素系统 视网膜病 早产儿 ALISKIREN 血管内皮生长因子 

分 类 号：R544.1[医药卫生—心血管疾病]