聚(β-氨基酯)肿瘤靶向给药系统的研究进展  

Poly(β-amino esters)-based barriers for tumor targeted delivery system

作　　者：李伟男[1] 徐琪[1] 王艳宏[1] 陈大为[2] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《药学学报》2015年第4期434-439,共6页Acta Pharmaceutica Sinica

摘　　要：聚(β-氨基酯)[poly(β-amino esters),PBAE]是一类p H敏感、低毒、合成方法简单且结构多样的药物载体,在肿瘤靶向给药系统中具有广阔的应用前景。本文主要总结了PBAE的结构特点和靶向递药特性,重点介绍PBAE作为靶向递药系统的应用形式和基于PBAE递送不同抗癌药物的肿瘤靶向给药系统。Poly（β-amino esters）（PBAE） are used for drug carrier and have many advantages, such as p H-sensitivity, low toxicity, structural diversity and the synthetic method of PBAE is easy. Therefore they are possessed broad application prospect in tumor-targeted drugs delivery systems. In this paper, the structural features and target drugs delivery property of PBAE are reviewed. The application forms of PBAE and different anti-cancer drugs loaded in the copolymer for tumor-targeted drugs delivery systems are introduced particularly.

关 键 词：聚(β-氨基酯) 药物载体 P H敏感 肿瘤靶向 

分 类 号：R943[医药卫生—药剂学]