Structural dissection of Hippo signaling  

作　　者：Zhubing Shi Shi Jiao Zhaocai Zhou 

机构地区：[1]National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [2]School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

出　　处：《Acta Biochimica et Biophysica Sinica》2015年第1期29-38,共10页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the 973 program of the Ministry of Science and Technology of China （No. 2012CB910204）, the National Natural Science Foundation of China （Nos. 31270808, 31300734, 31470736, and 31470868）, the Science and Technology Commission of Shanghai Municipality （Nos. 11JC14140000 and 13ZR1446400）, and the ＇Cross and Cooperation in Science and Tech- nology Innovation Team＇ Project of the Chinese Academy of Sciences.

摘　　要：The Hippo pathway controls cell number and organ size by restricting cell proliferation and promot- ing apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlates with many pathological conditions, especially cancer. Hippo signaling also plays important roles in tissue regeneration and stem cell biology. Therefore, the Hippo pathway is recog- nized as a crucial target for cancer therapy and regeneration medicine. To date, structures of several key components in Hippo signaling have been determined. In this review, we summarize current available structural studies of the Hippo pathway, which may help to improve our understanding of its regulatory mechanisms, as well as to facilitate further functional studies and potential thera- peutic interventions.The Hippo pathway controls cell number and organ size by restricting cell proliferation and promot- ing apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlates with many pathological conditions, especially cancer. Hippo signaling also plays important roles in tissue regeneration and stem cell biology. Therefore, the Hippo pathway is recog- nized as a crucial target for cancer therapy and regeneration medicine. To date, structures of several key components in Hippo signaling have been determined. In this review, we summarize current available structural studies of the Hippo pathway, which may help to improve our understanding of its regulatory mechanisms, as well as to facilitate further functional studies and potential thera- peutic interventions.

关 键 词：Hippo pathway three-dimensional structure protein-protein/DNA interaction regulatory mechanism 

分 类 号：Q959.842[生物学—动物学] S512.101[农业科学—作物学]