益心泰颗粒对慢性心力衰竭兔心肌重构的影响  

Effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure

作　　者：郭志华[1] 李雅[2] 吴刚强[1] 唐云[1] 毛湘屏[3] 王月爱[1] 孙涛[1] 

机构地区：[1]湖南中医药大学第一附属医院,长沙410007 [2]湖南中医药大学药学院 [3]湖南中医药大学第二附属医院

出　　处：《中国医师杂志》2015年第3期340-342,346,共4页Journal of Chinese Physician

基　　金：国家自然科学基金资助项目（81373816）;湖南省研究生科研创新项目（CX20138327）

摘　　要：目的：探讨益心泰颗粒对慢性心力衰竭（ CHF）兔心肌重构的影响。方法用阿霉素建立CHF家兔模型，将造模成功的家兔分为模型组、益心泰低、中、高剂量组和氯沙坦钾组；另设正常对照组。灌胃4周后观察超声心动图指标、心肌重构指标。结果与模型组比较，各用药组左心室后壁（LVPW）厚度、左心室收缩末期内径（LVIDs）、左心室舒张末期内径（LVIDd）、心脏指数（CI）及左心室重量指数（ LVWI）明显降低，差异有统计学意义（ P ＜0．05， P ＜0．01）；与模型组比较，益心泰中、高剂量组室间隔厚度（IVS）显著降低，差异有统计学意义（ P ＜0．01）。与益心泰低剂量组比较，益心泰中、高剂量组IVS、LVPW、CI、LVWI降低，差异有统计学意义（ P ＜0．05， P ＜0．01）；益心泰高剂量组LVIDs及LVIDd均明显降低，差异有统计学意义（ P ＜0．05）。结论益心泰颗粒能改善CHF兔心肌重构，且益心泰中、高剂量组疗效明显优于低剂量组。Objective To explore the effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure （ CHF） .Methods The rabbit model of CHF with adriamycin was established. These successful CHF models of rabbits were divided into model group, high,middle, and low dose of Yix-intai groups, losartan potassium group, and normal control group.Echocardiographic indexes and myocardi-al remodeling indexes were measured after 4 weeks of medication.Results Compared to the model group, the left ventricular posterior wall （LVPW）, left ventricular internal diameter at end-systole （LVIDs）, left ventricular internal diameter at end-diastole （ LVIDd） , cardiac index （ CI） , and left ventricular mass index （LVWI） of the treatment groups were decreased （ P 〈0.05 or P 〈0.01）, and the interventricular septum （ IVS） of the middle and high Yixintai groups was decreased significantly （ P 〈0.01 ） .Compared to the low dose of Yixintai group, the IVS, LVPW, CI, and LVWI of the middle and high Yixintai groups were decreased （ P 〈0.05 or P 〈0.01） , and the LVIDs and LVIDd of the high Yixintai group were decreased （ P 〈0.05 ） .Conclusions Yixintai granule can improve myocardial remodeling in rabbits with CHF. Meanwhile, the curative effect of medial and high groups of Yixintai is better than the low dose group.

关 键 词：心力衰竭/病理学/中药疗法 心室重构/药物作用 心血管药物(中药)/投药和剂量 

分 类 号：R285.5[医药卫生—中药学]