心血管支架材料生物相容性:国际发展态势的文献计量学分析  

Cardiovascular stent biocompatibility: bibliometric analysis of the international developmental trend

作　　者：李轩 石春来 王雪艳 张明 

机构地区：[1]辽宁省金秋医院心内科,辽宁省沈阳市110016

出　　处：《中国组织工程研究》2015年第8期1267-1271,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:心血管支架置入后血管再狭窄的确切发生机制尚不明确,减小置入后血管再狭窄的发生率就显得日益紧迫,置入后血管再狭窄除了与支架本身的抗腐蚀性、杨氏模量、屈服强度、材料柔顺性等生物力学有关外,还与置入后宿主的炎症反应、内皮细胞增殖、纤维组织细胞增生等生物相容性有关。目的:以汤森路透Web of Science数据库及北美临床试验注册中心的信息为数据源,分析国际心血管支架材料生物相容性研究文献趋势,以期为该领域研究提供可借鉴的依据。方法:1被收录的文章及以关键词"cardiovascular stent"(心血管支架),"biocompatibillty"(生物相容性)进行检索。2检索文献时间范围10年(2005至2014年)。3检索信息源:Web of Science数据库和北美临床试验注册中心的临床试验项目。结果与结论:1以Web of Science数据库2005至2014年收录的心血管支架材料生物相容性相关的2 875篇文献为研究对象,利用Web of Science数据库文献分析报告以及导出信息功能进行文献分析,得到8篇被引频次较高的经典文献。2在汤森路透Web of Science数据库,2005至2014年关于心血管支架材料生物相容性发表的文献共2 875篇。美国发文量最多,931篇,占总数比重最大,为32.383%;2005至2014年发表心血管支架材料生物相容性的研究文献较多的机构是美国哈佛大学,美国布莱根妇女医院,奥地利维也纳医科大学,荷兰鹿特丹伊拉斯姆斯大学,美国哥伦比亚大学;American Journal of Cardiology(《美国心脏病学杂志》)发表此领域文献最多,117篇,占全部文献的4.070%;近年来,国际心血管支架材料生物相容性相关文献呈总体逐渐上升的趋势;2005至2014年,在2 875篇心血管支架材料生物相容性的研究文献中来自中国的文章有223篇,文章数量位居第4,说明中国在此领域的科研成果较多。32005至2014年,在北美临床试验注册中心注册的心血管支架BACKGROUND：As the exact mechanism of vascular restenosis after cardiovascular stent implantation is unclear, to reduce the incidence of restenosis after implantation becomes increasingly urgent. The occurrence of vascular restenosis after stent implantation is associated with the corrosion resistance of stents, Young’s modulus, yield strength and material flexibility, as wel as the host’s inflammatory response, endothelial cel proliferation, and fibrous tissue proliferation after stent implantation. OBJECTIVE： To analyze the international research trend of cardiovascular stent biocompatibility based on data from Web of Science and Clincaltrials.gov, in order to provide a reference basis for relevant studies. METHODS：（1） Keywords of “cardiovascular stent” and “biocompatibility” were used for article retrieval. （2） The retrieval time was from 2005 to 2014. （3） Information sources： Web of Science and Clincaltrials.gov. RESULTS AND CONCLUSION： （1） Totaly 2 875 articles included in Web of Science （2005-2014） were enroled and analyzed using analytic tools of the Web of Science. Then, eight articles with high citation frequency were obtained. （2） There are 2 875 articles addressing the biocompatibility of cardiovascular stent materials included in the Web of Science （2005-2014）, among which, 931 articles come from the U.S.A and account for 32.383%. During 2005-2014, the institutions publishing literatures about biocompatibility of cardiovascular stent materials are ranked as folows： Harvard University, Brigham and Women’s Hospital, Medical University of Vienna, Erasmus University Rotterdam, Columbia University.American Journal of Cardiology has published 117 relevant articles, which ranks the first in this field, and the number of published literature accounts for 4.070% of al literature. In recent years, international literature about cardiovascular stent biocompatibility shows an overal gradual upward trend. Of the 2 875 articles published from 2005 to 2014, 223

关 键 词：生物材料 材料相容性 心血管疾病 心血管支架 生物相容性 WEB of Science数据库 

分 类 号：R318[医药卫生—生物医学工程]