人工血管材料血液相容性及表面改性  

Hemocompatibility and surface modification of artificial blood vessel materials

作　　者：何艳平[1] 马德春[1] 李磊[1] 张丽[1] 郑爽[1] 董可欣 

机构地区：[1]吉林大学第二医院骨科,吉林省长春市130041

出　　处：《中国组织工程研究》2015年第8期1272-1276,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:人工血管取于合成材料,是最常用的血管代用品,如何提高血管的通畅性和人工血管材料的相容性是在近年来人工血管研究的重点。目的:综述人工血管材料的生物相容性和血液相容性,归纳近年来国际在生物材料和血液相互作用研究方面出现的一些新方法和视点。方法:由第一作者用计算机检索万方数据库、中国期刊全文数据库和PubMed数据库2001至2014年的文献,检索词分别为"人工血管,生物材料;Biomaterials,Artificial blood vessels"。结果与结论:血液相容性材料的研究虽然历经了很多年,但目前仍然处于探索阶段。血液相容性的影响因素繁多,除血液固有成分外,材料表面界面特征起着决定性作用。目前,材料表面界面特征优化及改性已成为提高其血液相容性的重要途径,但现有的评价体系仍存在一些问题,如敏感指标和有效阳性对照材料的选择及其评价结果量化等。因此良好血液相容性材料的研制及合理、高效血液相容性评价体系的建立依然需要不断努力。BACKGROUND：Artificial blood vessels made from synthetic materials are the most commonly used blood vessel substitutes. How to improve the patency of the blood vessels and the compatibility of artificial blood vessel materials is in the focus of research in recent years. OBJECTIVE：To review the biocompatibility and hemocompatiblity of artificial blood vessel materials, and to summarize a number of new methods and viewpoints appearing in international biomaterial and blood interaction research in recent years. METHODS： Wanfang database, Chinese Journal Ful-text Database and PubMed database were retrieved by the first author for relevant articles published from 2001 to 2014, using the key words of “artificial blood vessels, biomaterials” in Chinese and English, respectively. RESULTS AND CONCLUSION： Research on the hemocompatibility of materials, although after many years, is stil in the exploratory stage. There are many factors influencing material hemocompatibility, and in addition to the inherent blood components, surface and interface characteristics of the materials play a decisive role. Currently, surface and interface features optimization and modification has become an important way to improve the blood compatibility, but the existing evaluation system appears to have some problems, such as the selection and quantitative evaluation of sensitive indicators and positive control materials. Therefore, to develop artificial materials with good hemocompatibility and to establish rational and high-efficient blood compatibility evaluation system stil need further studies.

关 键 词：生物材料 材料相容性 人工血管 血液相容性 生物相容性 综述 

分 类 号：R318[医药卫生—生物医学工程]