用于心血管医疗装置的聚合物表面构建与生物相容性研究Ⅲ——聚合物生物材料表面的凝血及抗凝血涂层改性（英文）  

Phase Ⅲ study on surface construction and biocompatibility of polymer materials as cardiovascular devices: coagulant and anti-coagulant surface modification

作　　者：陈宝林[1] 王东安[2,3] 

机构地区：[1]呼伦贝尔学院科研处,内蒙古自治区呼伦贝尔市021008 [2]浙江大学高分子科学研究所,浙江省杭州市310027 [3]Department of Pharmaceutical Sciences, University of Tennessee Health Science Center

出　　处：《中国组织工程研究》2015年第8期1277-1283,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:研制用于心血管组织工程的新型植(介)入型聚合物材料(表面),从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察各种相应改性表面的生物相容性、血液相容性和细胞相容性。方法:检索1983至2014年PubMed数据库及万方数据库。英文检索词为"biocompatibility,blood compatibility,biomedical materials,biomedical polymer materials",中文检索词为"生物相容性材料;血液相容性材料;生物医用材料;医用高分子材料"。排除与研究目的相关性差及内容陈旧、重复的文献,保留与生物医用高分子材料的血液相容性研究,进行归纳总结。结果与结论:通过对血液与植入物间的相互作用和生物材料表面的抗凝血涂层改性两个方面的归纳分析,从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察了各种相应改性表面的生物相容性、血液相容性和细胞相容性。研制用于心血管组织工程的新型植(介)入型聚合物材料(表面)关键在于对聚合物生物材料表面的凝血及抗凝血涂层改性以及对其相应生物相容性与内皮细胞相容性的研究。通过对心血管医疗用聚合物生物材料的种类与应用及其心血管医疗器件和可植入性软组织替代物的深入研究可以发现表面与本体的差别则将体现在从表面向本体延伸的很多层分子上,而2种主要因素决定了其包括本体/表面差异及表面相分离在内的本体/表面行为,即表面能和分子运动性。如果考虑到对本体-表面的组成差异的理解,则还必须追加另以附加决定因素,即各组分的结晶行为。BACKGROUND： As the cardiovascular device, biomaterials applied under the blood-contact conditions should have anti-thrombotic, anti-biodegradable and anti-infective properties. OBJECTIVE： To develop novel polymer materials for implantation and intervention in cardiovascular tissue engineering and to explore the biocompatibility, blood compatibility and cytocompatibUity of the surface-modified polymer biomaterials based on the coagulant and anti-coagulant coating modification. METHODS： We retrieved PubMed and WanFang databases for relevant articles publishing from 1983 to 2014. The key words were ＂biocompatibility, blood compatibility, biomedical materials, biomedical polymer materials＂ in English and Chinese, respectively. Those unrelated, outdated and repetitive papers were excluded. Literatures addressing the blood compatibility of biomedical polymer materials were summarized. RESULTS AND CONCLUSION： The blood-implant interaction and the anti-coagulant surface modification of biomaterials were analyzed. The biocompatibility, blood compatibility and cytocompatibility of the surface-modifiedpolymer biomaterials were determined based on the coagulant and anti-coagulant coating modification. The coagulant and anti-coagulant surface modification of polymer biomaterials and the research on their biocompatibility and endothelial cell compatibility are crucial for developing novel polymer materials for implantation and intervention in cardiovascular tissue engineering. Through in-depth studies of the types and applications of polymer biomatedals, cardiovascular medical devices and implantable soft tissue substitutes, the differences between the surface and the body will be reflected in the many layers of molecules extending from the surface to the body. Two major factors, surface energy and molecular mobility, determine the body/surface behaviors that include body/surface differences and phase separation. Considering the difference between the body/surface composition, an additional determinant is indispens

关 键 词：生物材料 材料相容性 聚合物材料 聚合物生物材料 生物医用聚合物材料 生物相容性 血液相容性 细胞相容性 抗凝血涂层改性 

分 类 号：R318[医药卫生—生物医学工程]