念珠菌耐药机制的研究进展  

The research progress on antifungal resistance mechanisms of Candida spp.

作　　者：贺小圆 赵明峰[1,2] 

机构地区：[1]天津医科大学一中心临床学院 [2]天津市第一中心医院血液科,天津300192

出　　处：《中国真菌学杂志》2015年第1期49-53,共5页Chinese Journal of Mycology

基　　金：天津市自然科学基金(13JCYBJC23400);天津市卫生局科技基金攻关项(13KG106)

摘　　要：近年来,真菌感染尤其是机会性真菌感染的发生率和病死率呈不断上升的趋势,这主要与真菌耐药和抗真菌药物品种有限有关。念珠菌是人体内的重要条件致病真菌,其常见的耐药机制包括靶酶的改变、靶位的缺乏、真菌细胞膜对药物的通透性下降、多药耐药蛋白表达增高、固醇合成旁路下游的改变、生物膜的形成等,最新文献报道分泌型天冬氨酸蛋白酶在念珠菌的耐药形成中存在一定作用。该文就念珠菌感染的流行病学和念珠菌的耐药机制两个方面进行综述。In recent years,the incidence and mortality of fungal infection,especially the opportunistic fungal infection have been increasing.This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.Candida species are opportunistic fungi in human body.The common antifungal resistance mechanisms include the changes of the target enzyme,the lack of target site,the drug permeability decline of fungal cell membrane,the increased expression of multi-drug resistance protein,the change of cholesterol synthesis bypass,the biofilm formation and so on. The latest literature reports that secreted aspartic proteinases have a role in antifungal resistance of Candida spp..In this article,the epidemiology of Candida spp.infection and its possible antifun-gal resistance mechanisms are reviewed briefly.

关 键 词：念珠菌 真菌耐药 耐药机制 分泌型天冬氨酸蛋白酶 

分 类 号：R379.4[医药卫生—病原生物学]