双波长强脉冲光联合0.1%他克莫司软膏治疗玫瑰痤疮疗效观察  

Efficacy of combination therapy of dual wavelength Intense Pulsed Light and topical tacrolimus 0.1% ointment on treatment of rosacea

作　　者：万建勣[1] 肖洁平[1] 丁街生[1] 董秀芹[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)皮肤科,广东广州510032

出　　处：《中国美容医学》2015年第5期47-51,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察双波长强脉冲光(intense pulsed light,IPL)联合0.1%他克莫司软膏治疗玫瑰痤疮的疗效及安全性。方法:将65例I型及II型玫瑰痤疮患者随机分为联合组、IPL组及他克莫司(Tacrolimus,TLM)治疗组。联合组及IPL组采用双波长IPL治疗,每2周1次,共治疗3次,同时,联合组及TLM组采用0.1%他克莫司软膏,每日2次,连续8周。由两位盲态医生对患者的皮损评分并记录不良反应,共8周。结果:研究第8周,联合组、IPL组及TLM组治疗前后积分差值分别为7.76±2.37、7.41±2.06及5.40±2.92,差异有显著性(P<0.05);三组总有效率分别为84.85%、82.35%及46.66%;均未见严重不良反应。结论:IPL及0.1%他克莫司软膏治疗玫瑰痤疮均安全,IPL的短期疗效优于0.1%他克莫司软膏,IPL短期联合0.1%他克莫司软膏与单独采用IPL比较未体现出明显优势。Objective To evaluate the efficacy and safety of combination therapy of dual wavelength Intense Pulsed Light （IPL） and topical tacrolimus 0.1% ointment on treatment of rosacea. Methods Sixty-five subjects with erythematotelangiectatic rosacea or papulopustular rosacea were divided randomly into three groups. Group combination and group IPL were treated with 3 sessions of IPL at 2 weeks intervals, group combination and group TLM received tacrolimus 0.1% ointment twice daily for 8 weeks.Scores and side effects were evaluated and recorded by physician＇s assessment by two blinded dermatologists for 8 weeks. Results At 8th week, the decline in severity scores of the group combination,IPL and TLM was 7.76 ± 2.37,7.41 ± 2.06 and 5.40 ± 2.92 respectively,the differences between the three groups were significant （P〈0.05）.Total efficiencies of the group combination, group IPL and group TLM were 84.85, 82.35% and 42.11% respectively.No serious adverse event was observed in either group. Conclusion IPL and tacrolimus 0.1% ointment are both safe for treatment of rosacea,IPL improves rosacea better than tacrolimus 0.1% ointment for 8 weeks＇treatment,short- term combination therapy of IPL and tacrolimus 0.1% ointment on rosacea has no clear advantage over that of IPL.

关 键 词：强脉冲光 他克莫司软膏 玫瑰痤疮 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]