人胚胎干细胞源性间充质干细胞的研究进展  

Progress in the Study of Human Embryonic Stem Cell Derived Mesenchymal Stem Cells

作　　者：冯年花[1] 

机构地区：[1]首都医科大学附属北京朝阳医院医学研究中心,北京100020

出　　处：《中国细胞生物学学报》2015年第3期409-415,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81170640)资助的课题~~

摘　　要：人胚胎干细胞源性间充质干细胞(human embryonic stem cell derived mesenchymal stem cells,h ESC-MSCs)是由胚胎干细胞诱导分化而来的间充质干细胞,具有成体间充质干细胞(mesenchymal stem cells,MSCs)相似的生物学特性和功能,由于其来源丰富、均一性好,受到广泛关注,是MSCs的一种新的获取途径。其应用避免了胚胎干细胞直接应用而面临的致瘤性问题,是胚胎干细胞应用于疾病治疗的一种新的形式,具有广阔的应用前景。然而,h ESC-MSCs真正运用于临床治疗仍面临较多的问题需要解决。该文就h ESC-MSCs的诱导分化、生物学特性、应用前景及目前尚存在的问题作一综述。Human embryonic stem cell derived mesenchymal stem cells（h ESC-MSCs） are a kind of mesenchymal stem cells（MSCs） differentiated from human embryonic stem cells（h ESCs）. h ESC-MSCs possess similar properties with adult MSCs, and have attracted extensive attentions for its rich source and good homogenecity. So it is a new approach to obtain MSCs from h ESCs. The application of h ESC-MSCs avoid tumorigenesis caused by using h ESCs directly. So it is a good format to adopt h ESC-MSCs instead of h ESCs in disease therapy. However, there are several problems remaining to be settled before its application. Here, we mainly described the differentiation, biological characteristics and application of h ESC-MSCs, as well as challenges that should be overcome before used in clinic.

关 键 词：间充质干细胞 人胚胎干细胞 再生医学 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]