二氧化硅@羟基磷灰石颗粒的制备及其药物装载与体外释放行为研究  

Synthesis of Core-Shell Structured Silica@Hydroxyapatite for Drug Storage and Its Release Behavior in Vitro

作　　者：李成峰[1] 王燕云[1] 杜健[2] 陆昊[1] 葛筱璐[3] 

机构地区：[1]山东理工大学材料科学与工程学院,淄博255049 [2]山东省滨州市公路管理局,滨州256600 [3]山东理工大学理学院,淄博255049

出　　处：《人工晶体学报》2015年第3期830-835,共6页Journal of Synthetic Crystals

基　　金：山东理工大学博士基金项目(406017);山东省高等学校科技计划项目(J11LD52);山东省自然科学基金(ZR2013EML008)

摘　　要：以改性的Stber方法制备二氧化硅核心颗粒,并用改性的Pechini方法在其表面沉积羟基磷灰石壳层,制备得到具有核壳结构的二氧化硅@羟基磷灰石颗粒。通过扫描电子显微镜、X射线衍射分析和红外光谱分析手段表征颗粒的物相和结构,确定颗粒的形成机制为羟基磷灰石壳层在聚乙二醇-柠檬酸作用下均匀地沉积在非晶态二氧化硅表面。含亚甲基蓝的二氧化硅@羟基磷灰石药物颗粒在磷缓冲液（p H=7.2~7.4）和lysosome-like缓冲液（p H=4.7）中的释放行为表明药物释放对颗粒结构和溶液的p H值非常敏感。Silica particle as core material was prepared by a modified Stber method,and then core-shell structured silica@ hydroxyapatite was prepared through a modified Pechini process. The phase and structure of the samples were characterized by scanning electron microscopy,X-ray diffraction and Fourier transform infrared spectrometer. The formation mechanism of core-shell structured powder is that hydroxyapatite shell is deposited on the surface of amorphous silica with assist of polyethylene glycol and citric acid. The sustainedrelease behaviors of drug from silica@ hydroxyapatite powders with drug storage are seriously depended on coreshell structure and p H value of phosphate buffered saline（ p H =7. 2-7. 4） or lysosome-like buffer（ p H =4. 7）.

关 键 词：药物载体 羟基磷灰石 二氧化硅 核壳结构 药物释放 

分 类 号：TB332[一般工业技术—材料科学与工程]