薄型子宫内膜冻融胚胎移植周期中应用雌二醇/雌二醇地屈孕酮的疗效观察  

The Effect of Femoston on Endimetrial Thickness and Pregnancy Outcome in Frozen-Thawed Embryo Transfer Cycles of Patients with Thin Endometrium

作　　者：赵诗艺 刘英[1] 杨晓葵[1] 张军[1] 余兰[1] 

机构地区：[1]首都医科大学附属北京妇产医院,北京100026

出　　处：《实用妇产科杂志》2015年第4期270-273,共4页Journal of Practical Obstetrics and Gynecology

基　　金：国家自然科学基金项目(编号:81471520);北京市自然科学基金项目(编号:5122015);北京市科技新星基金项目(编号:H020821200190);北京市卫生系统高层次卫生技术人才培养项目

摘　　要：目的:探讨雌二醇/雌二醇地屈孕酮(芬吗通)对薄型子宫内膜患者冻融胚胎移植(FET)周期中的子宫内膜厚度及妊娠结局的影响。方法:回顾性分析2013年1月至2014年6月56例患者62个FET周期的临床资料,根据内膜准备方案分为戊酸雌二醇(补佳乐)组29例(34个周期)和芬吗通组27例(28个周期),比较两组患者的一般情况、基础激素水平、超排卵情况、用药量及用药前后子宫内膜增幅和妊娠情况的差异。结果:两组一般情况、基础激素水平、超排卵情况及用药后妊娠情况比较,差异均无统计学意义(P>0.05)。两组用药前、用药后子宫内膜厚度比较,差异无统计学意义(P>0.05);但用药后子宫内膜厚度均增加(均>8 mm),分别与用药前比较,差异均有统计学意义(P<0.05);芬吗通组用药后子宫内膜厚度增幅(2.58±1.69 mm)大于补佳乐组(2.00±0.99 mm),差异有统计学意义(P<0.05)。芬吗通组用药剂量(65.36±40.22 mg)少于补佳乐组(80.50±63.14mg),差异有统计学意义(P<0.05)。结论:补佳乐及芬吗通均可改善薄型子宫内膜患者的内膜厚度,但芬吗通用药量较少且效果更明显,并可获得与补佳乐患者相似的妊娠结局。Objective：To study the effect of Femoston in endometrial thickness and pregnancy rate in patients with thin endometrium. Methods：62 frozen-thawed embryo transfer（FET） cycles in 56 patients with endometrium thickness under 8 mm at the day of HCG or urine LH peak in our center from Jan.2013 to Jun.2014 were retro- spectively analyzed. All cases were divided into two groups according to the protocol of endometrial preparation： 29 cases in Progynova group,27 cases in Femoston group. Patients＇ general condition, hormone levels,number of retrieved oocytes,fertility rate,the endometrial thickness before and after Progynova or Femoston and pregnan- cy outcome were compared between the two groups. Results：There was on significant difference on the basic conditions, basic hormone level, superovulation condition and pregnancy rate between these two groups （P 〉 0. 05）. Before and after using Progynova or Femoston, the difference on the endometrial thickness between the two groups were without statistically significant（ P 〉 0.05 ）. After using Progynova or Femoston, the thickness of endometrium （ 〉 8 mm） was increased statistically significantly than before in both groups （ P 〈 0.05）. The growth of endometrial thickness of Femoston group（2.58 ± 1.69 mm）was more than that of Progynova group（2. 00± 0. 99 mm） ,the differences were significant（ P〈0. 05）. The dosage of Femoston（65.36 ±40. 22 mg） for endome- trial preparation was less than that of Progynova（80. 50 ±63. 14 mg）, the differences were significant （P 〈 0. 05）. Conclusions,Both Femoston and Progynova could significantly improve the endometrial thickness of pa- tients with thin endometrium. But patients using Femoston may have the same pregnancy rate compared with Progynova with less dosage.

关 键 词：冻融胚胎移植 人工周期 妊娠率 子宫内膜容受性 薄型子宫内膜 雌二醇/雌二醇地屈孕酮 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]