高危型人乳头瘤病毒负荷量与宫颈病变的关系研究  

Investigation of Cervical Lesions with the High Risk HPV Viral Load

作　　者：杨亮亮[1] 朱义保[1] 

机构地区：[1]江西省妇幼保健院,江西南昌330006

出　　处：《实用妇产科杂志》2015年第4期282-284,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:研究高危型人乳头瘤病毒(HPV)病毒负荷量与不同级别宫颈病变的关系。方法:收集慢性宫颈炎102例,CINⅠ104例,CINⅡ120例,CINⅢ109例,宫颈癌94例,HC-Ⅱ法检测高危型HPV病毒负荷量。结果:慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ、宫颈癌高危型HPV感染率分别为41.18%、82.69%、89.17%、96.33%、91.49%,负荷量中位数分别为0.77 pg/ml、18.83 pg/ml、102.07 pg/ml、254.16 pg/ml、213.59 pg/ml,不同级别宫颈病变间的高危型HPV感染率及负荷量差异有统计学意义(P<0.05,P<0.01)。6层高危型HPV病毒负荷量分层间不同宫颈病变程度比较,差异有统计学意义(P<0.01),但当剔除病毒负荷量<5 pg/ml的病例时,差异则无统计学意义(P>0.05)。结论:高危型HPV病毒负荷量与宫颈病变程度的关系不明显。Objective： To investigate the correlation between cervical lesions and high risk HPV viral load. Methods：102 chronic cervicitis patients,104 CIN Ⅰ patients,120 CIN Ⅱ patients,109 CIN Ⅲ patients and 94 cer- vical carcinoma patients were collected, high risk HPV viral load were tested in all these cases by HC- II method. Results： High risk HPV infection prevalence showed a progressive rise among the chronic cervicitis, CIN Ⅰ , CIN Ⅱ ,CIN Ⅲ and cervical carcinoma,the infection rate were 41.8% ,82.69% ,89. 17% ,96.33% ,91.49% ,and the viral load median were 0.77 pg/ml, 18.83 pg/ml, 102.07 pg/ml,254. 16 pg/ml,213.59 pg/ml, both of which made a made a statistical significances（ P 〈 0.05, P 〈 0.01 ）. When the viral load was divided into 6 groups, in ac- cord to the viral load median statistics, it also showed a significant difference （ P 〈 0.01 ）, while we deleted the groups low than 5 pg/ml, the statistical significance disappeared （ P 〉 0.05 ）. Conclusions. There is no obvious correlation between cervical lesions and high risk HPV viral load.

关 键 词：高危型人乳头瘤病毒 病毒负荷量 宫颈病变 

分 类 号：R711.74[医药卫生—妇产科学]