温敏性胶原基复合水凝胶的制备与表征(续)  

Preparation and Characterization of Temperaturesensitive Collagen Based Composite Hydrogel

作　　者：胡杨[1,2] 崔国廉[1,2] 林海[1,2] 但卫华[1,2] 刘兰[1,2] 但年华[1,2] 

机构地区：[1]四川大学皮革化学与工程教育部重点实验室,四川成都610065 [2]四川大学制革清洁技术国家工程实验室,四川成都610065

出　　处：《中国皮革》2015年第7期31-36,共6页China Leather

基　　金：国家自然科学基金项目(No:21276164);国家科技支撑计划项目(No:2011BAC06B11)

摘　　要：以合成的P(NIPAM-co-AAc)共聚物为温敏成分,制备PVA-P(NIPAM-co-AAc)-Col胶原基复合水凝胶。通过响应曲面设计分别对水凝胶的抗张强度、断裂伸长率、杨氏模量、在蒸馏水和生理盐水中的溶胀率、干态透水汽性、35℃和39℃的湿态透水汽性进行了研究。同时,进行不同制备参数的验证试验,以期建立一种以数学拟合方程对各响应值进行预测的方法。结果表明:采用响应曲面设计获得的回归拟合方程,在预测水凝胶性质时具有一定的准确性和可靠性,以P(NIPAM-co-AAc)共聚物作为温敏控件,能够获得具有温敏性的水凝胶。The PVA- P（NIPAM- co- AAc）- Col hydrogel was prepared with P（NIP AM-co- AAc） copolymer as temperature- sensitive material.The tensile strength,elongation at break,Young＇s modulus,the swelling ratio in distilled water and saline,the water vapor transmission rates（WVTR） in dry condition and in wet condition at 35℃ and 39℃ of hydrogel were determined via the Response Surface Methodology（RSM）.Meanwhile,the examination concerned was conducted in order to establish a method to predict response based on mathematical fitting equation.The results show that the fitting equations gained from RSM can predict the properties of the hydrogel in some extent.The hydrogels synthesized by P（NIPAM-co- AAc）copolymer is temperature- sensitive.The WVTR in wet condition can response with the change of temperature.

关 键 词：温敏性 胶原基复合水凝胶 响应曲面设计 数学方程拟合 性能预测 

分 类 号：TQ427.26[化学工程]