大黄对雌性幼年大鼠血清GnRH、LH、FSH、P、E2水平的影响  

INFLUENCES OF RHUBARB ON GNRH, LH, FSH, PAND E_2 LEVEL IN SERUM OF YOUNG FEMALE RATS

作　　者：刘梦杰[1] 佟继铭[1] 宋素英[2] 万慧杰[1] 卢宁[1] 张树峰[1] 

机构地区：[1]河北省中药研究与开发重点实验室/承德医学院中药研究所,河北承德067000 [2]河北联合大学中医学院

出　　处：《承德医学院学报》2015年第2期102-104,共3页Journal of Chengde Medical University

基　　金：河北省教育厅重大项目(2009301)

摘　　要：目的:观察大黄水提物对雌性幼年大鼠血清促性腺激素释放激素(Gn RH)、黄体生成素(LH)、卵泡刺激素(FSH)、孕酮(P)、雌二醇(E2)水平的影响。方法:4周龄雌性SD大鼠20只,随机分为正常对照组和大黄水提物2.0g/kg组,每组10只,连续灌胃给药30天。采用ELISA法检测各组大鼠血清Gn RH、LH、FSH、P、E2的水平。结果:与正常对照组大鼠比较,大黄水提物2.0g/kg组大鼠Gn RH、P、E2激素水平明显降低(P<0.05),LH、FSH激素水平明显升高(P<0.05)。结论:大黄水提物可明显影响雌性幼年大鼠下丘脑-垂体-卵巢轴的激素水平。Objective： To observe the influences of aqueous extract of Rhubarb on gonadotrophin releasing hormone（Gn RH）, luteinizing hormone（LH）, follicle-stimulating hormone（FSH）, progesterone（P） and estradiol（E2） level in serum of young female rats. Methods：20 4-week female SD rats were randomly divided into normal control group and Rhubarb aqueous extract（2.0g/kg） group, with 10 rats in each group. The Gn RH, LH, FSH, P and E2 level in serum of rats were detected by ELISA after the rats were lavaged with Rhubarb aqueous extract for 30-day. Results： Compared with rats in normal control group, the Gn RH, P and E2 level in serum of rats in Rhubarb aqueous extract group decreased obviously（P〈0.05）; LH and FSH level increased obviously（P〈0.05）.Conclusions： Rhubarb aqueous extract can infl uence the hormone level of hypothalamic-hypophyscal-ovarian axis of young female rats obviously.

关 键 词：大黄水提物 雌性幼年大鼠 Gn RH LH FSH P E2 

分 类 号：R285.5[医药卫生—中药学]