Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury  

作　　者：Jennifer Rodger Rachel M.Sherrard 

机构地区：[1]Experimental and Regenerative Neuroscience,School of Animal Biology,the University of Western Australia [2]Sorbonne Universités,UPMC Univ Paris 06 & CNRS,Institut de Biologie Paris Seine-B2A,UMR 8256 Biological Adaptation and Ageing,Paris France

出　　处：《Neural Regeneration Research》2015年第3期357-359,共3页中国神经再生研究（英文版）

摘　　要：While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cannot adequately control neuronal excitability and activity within the injured brain in order to induce repair. However, it is possible to non-invasively modulate brain plasticity using brain stimu- lation techniques such as repetitive transcranial （rTMS） and transcranial direct current stimulation （tDCS） techniques, which show promise for repairing injured neural circuits （Henrich-Noack et al., 2013; Lefaucher et al., 2014）. Yet we are far from having full control of these techniques to repair the brain following neurotrauma and need more fundamen- tal research （Ellaway et al., 2014; Lefaucher et al., 2014）. In this perspective we discuss the mechanisms by which rTMS may facilitate neurorehabilitation and propose experimental techniques with which magnetic stimulation may be investi- gated in order to optimise its treatment potential.While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cannot adequately control neuronal excitability and activity within the injured brain in order to induce repair. However, it is possible to non-invasively modulate brain plasticity using brain stimu- lation techniques such as repetitive transcranial （rTMS） and transcranial direct current stimulation （tDCS） techniques, which show promise for repairing injured neural circuits （Henrich-Noack et al., 2013; Lefaucher et al., 2014）. Yet we are far from having full control of these techniques to repair the brain following neurotrauma and need more fundamen- tal research （Ellaway et al., 2014; Lefaucher et al., 2014）. In this perspective we discuss the mechanisms by which rTMS may facilitate neurorehabilitation and propose experimental techniques with which magnetic stimulation may be investi- gated in order to optimise its treatment potential.

关 键 词：TMS Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury 

分 类 号：R651.15[医药卫生—外科学]