脂肪因子Chemerin在炎症和代谢综合征中的双重效应  

Double effects of Chemerin on inflammation and metabolic syndrome

作　　者：李雪梅[1] 翟丽东[2] 

机构地区：[1]天津医科大学代谢病医院、内分泌研究所、卫生部激素与发育重点实验室,天津市300070 [2]天津医科大学基础医学院人体解剖和组织胚胎系,天津市300070

出　　处：《中国组织工程研究》2015年第7期1094-1098,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:近年多项临床及基础研究显示脂肪因子chemerin与代谢综合征密切相关。目的:综述脂肪因子chemerin在炎症和肥胖、高血压及糖脂代谢中的作用及机制,概括脂肪因子chemerin与炎症和代谢综合征的关系。方法:由第一作者检索1990至2014年Pub Med数据库以及万方数据库脂肪因子chemerin相关的文献,并进行系统整理、总结和分析。结果与结论:研究表明脂肪因子chemerin水平与体脂含量、能量代谢、炎症相关,在肥胖和代谢综合征病理生理过程中扮演了重要角色。由于脂肪因子chemerin在炎症和代谢中的双重作用,它可能成为连接慢性炎症和肥胖及其相关疾病的一个关键因子。脂肪因子Chemerin在不同的炎症状态下作用不同,可能与其在不同的炎症环境中裂解方式的不同有关,但并没有明确脂肪因子chemerin在肥胖和代谢综合征中的功能。需要进一步研究明确血清脂肪因子chemerin水平与肥胖和代谢综合征之间的关系。BACKGROUND：In recent years, a number of clinical and basic studies have shown that Chemerin is closely associated with the metabolic syndrome. OBJECTIVE：Through the review of Chemerin’s role and mechanism in inflammation and obesity, hypertension and lipid metabolism, to summarize the relationship of Chemerin with inflammatory and metabolic syndrome. METHODS：Literatures about Chemerin were retrieved in PubMed database and Wanfang database by the first author from 1990 to 2014. Systematic col ation, summary and analysis were performed.RESULTS AND CONCLUSION：The Chemerin level is associated with body fat content, energy metabolism and inflammation. Chemerin plays an important role in the pathophysiology of obesity and metabolic syndrome. Due to the dual role of Chemerin in inflammation and in metabolism, it may become a key factor linking chronic inflammation, obesity and related diseases. Under different inflammatory states, Chemerin plays different roles, which may be related to different cleavage ways under different inflammatory environments, but Chemerin has no explicit effects in obesity and metabolic syndrome. Further research is needed for the clear relationship of serum levels of Chemerin with obesity and metabolic syndrome.

关 键 词：组织构建 组织工程 脂肪因子 CHEMERIN 炎症 代谢综合征 肥胖 高血压 糖尿病 

分 类 号：R318[医药卫生—生物医学工程]