585nm脉冲激光修复病理性瘢痕的系统评价  

A systematic review of 585 nm pulsed dye laser for repair of pathological scars

作　　者：宋黎[1] 叶俊儒[1] 陆茂[1] 彭科[1] 沈跃莉[1] 朱江婷[1] 

机构地区：[1]成都医学院第一附属医院皮肤性病科,四川省成都市610500

出　　处：《中国组织工程研究》2015年第7期1104-1111,共8页Chinese Journal of Tissue Engineering Research

基　　金：四川省2012年卫生厅课题(120480)~~

摘　　要：背景:585 nm脉冲激光作为一种临床广泛应用的治疗病理性瘢痕的方法,其疗效及安全性未得到证实。目的:评价585 nm脉冲激光治疗病理性瘢痕的有效性及安全性。方法:计算机检索Cochrane图书馆临床对照试验库等。对同质研究使用Revman 5.2软件进行Meta分析。结果与结论:纳入6个研究,208个瘢痕。结果显示585 nm脉冲激光在改善温哥华量表评分方面优于空白对照组,差异有显著性[P<0.000 01,WMD=-2.79,95%CI(-3.12,-2.46)]。585 nm脉冲激光在总体改善瘢痕情况方面效果是肯定的,但不能得到在具体改善瘢痕大小、红斑、弹性及硬度等单一方面确切有效的证据。585 nm脉冲激光并不优于其他治疗方法。可以认为585 nm脉冲激光治疗病理性瘢痕是安全的。由于纳入的研究数量较少,结果具有一定的偏倚性。BACKGROUND：585 nm pulsed dye laser is widely used in clinical practice for pathological scars, but the efficacy and safety have not been proved. OBJECTIVE：To evaluate the effectiveness and safety of 585 nm pulsed dye laser in the treatment of pathological scars. METHODS：A computer search of the Cochrane Central Register of Control ed Trials and others was conducted. Meta-analyses were performed for the results of homogenerous studies by Revman 5.2 software. RESULTS AND CONCLUSION：Six studies including 208 pathological scars were enrol ed. Meta-analyses showed that the 585 nm pulsed dye laser was superior to the blank control group in the change of Vancouver burn scar assessment scale [P〈0.000 01, WMD=-2.79 and 95%CI （-3.12,-2.46）]. 585 nm pulsed dye laser seems to improve the overal texture of the scar;however, it is not confirmed to be effective in the improvement of erythema, size, elasticity and pliability of scars. 585 nm pulsed dye laser is not better than other treatments. It is suggested that it is safe to use 585nm pulsed dye laser in the treatment of pathological scars. It is susceptible to bias due to little sample size.

关 键 词：瘢痕 红斑 组织构建 组织工程 病理性瘢痕 585nm脉冲激光 增生性瘢痕 瘢痕疙瘩 温哥华量表 meta分析 系统评价 

分 类 号：R318[医药卫生—生物医学工程]