一种复方聚六亚甲基胍消毒液的配方筛选及杀菌效果研究  

Study on the formula and germicidal effiacy of a polyhexamethylene guanidine disinfectant

作　　者：林立旺[1] 黄育红[1] 周游[1] 

机构地区：[1]福建省疾病预防控制中心,福建福州350001

出　　处：《中国消毒学杂志》2015年第4期318-319,322,共3页Chinese Journal of Disinfection

摘　　要：目的研究一种复方聚六亚甲基胍消毒液及其相关性能,为实际应用提供科学依据。方法通过正交试验和悬液定量杀菌试验方法,对该复方聚六亚甲基胍消毒液配方和消毒相关性能进行实验室研究。结果该复方聚六亚甲基胍消毒液配方以聚六亚甲基胍和苯扎溴铵为主要杀菌成分,含量均为500 mg/L。以该复方聚六亚甲基胍消毒液原液作用1 min,对悬液内金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌杀灭对数值依次为6.13、6.19和5.72;对悬液内白色念珠菌作用5 min,杀灭对数值达4.06。结论该复方聚六亚甲基胍消毒液对细菌繁殖体和真菌具有快速杀灭效果。Objective To study the performance of one polyhexamethylene guanidine disinfectant,so as to provide basis for practical application. Methods The orthogonal test and suspension quantitative germicidal test were used to study the formula of the polyhexamethylene guanidine compound and its disinfection- related properties. Results Polyhexamethylene guanidine and benzalkonium were the main bactericidal ingredient,both content were 500 mg / L. The killing logarithm value of Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa exposed to the compound for 1 min were6. 13,6. 19 and 5. 72; that of Candida albicans exposed for 5 min was 4. 06. Conclusion The polyhexamethulene guanidine compound had rapid germicidal efficacy to vegetative forms and fungi.

关 键 词：聚六亚甲基胍 复方消毒液 正交试验 杀菌效果 

分 类 号：R187.1[医药卫生—流行病学]