某医院临床分离1895株医院感染致病菌分布及耐药性研究  

Pattern and drug resistance of clinical isolated 1895 strains of pathogens of nosocomial infection

作　　者：戴金荣[1] 杨运彩[1] 都琪[1] 

机构地区：[1]北京市第六医院,北京100007

出　　处：《中国消毒学杂志》2015年第4期343-345,共3页Chinese Journal of Disinfection

摘　　要：目的研究住院病人送检标本病原菌分布及其耐药性,为合理选用抗菌药物提供参考。方法采用标本分离鉴定技术和药敏试验方法,对某医院住院病人送检标本进行检测与分析。结果从住院感染患者送检标本中共分离病原菌1 895株,革兰阴性杆菌、革兰阳性球菌、真菌及其他病原体的构成比依次为58.15%、27.07%、9.7%和5.0%。检出的病原菌中,铜绿假单胞菌、鲍曼不动杆菌、大肠埃希菌、金黄色萄葡球菌和凝固酶阴性葡萄球菌分居前5位。革兰阴性菌中铜绿假单胞菌、鲍曼不动杆菌对亚胺培南、头孢曲松等抗菌药物耐药率均超过50%;金黄色葡萄球菌和肠球菌对亚胺培南、头孢曲松等耐药率超过50%。结论该医院临床分离病原菌以革兰阴性菌占主导,所检出的病原菌严重耐药来看,应加强细菌耐药性监测,指导临床合理使用抗菌药物。Objective To study the inpatient specimens of pathogenic bacteria distribution and drug resistance for the rational use of antimicrobial agents so as to provide reference. Methods The sample separation technique with identification and drug sensitivity method were used for detection and analysis of inpatient specimens. Results From the hospital infection in patients with isolated specimens of 1895 strains of pathogenic- bacteria,The gram negative bacteria,gram positive bacteria,fungi and other pathogens accounted for 58. 15%,27. 07%,9. 7%,and 5. 0% respectively. Pseudomonas aeruginosa,Bauman Acinetobacter and Escherichia coli,Staphylococcus aureus and Coagulase negative Staphylococcus were on the top 5 in the pathogenic bacteria detected. The resistant rates of gram negative bacilli to Imipenem,Ceftriaxone antibiotic were more than 50%; those of Staphylococcus aureus and Enterococcus to Imipenem,Ceftriaxone sodium and Piperacillin were more than 60%. Conclusion The pathogenic bacteria isolated from clinic was mainly Gram negative bacteria,and the detected pathogenic bacteria have serious drug resistance. So the monitoring of drug resistance should be strengthened and we should guide rational use of drug resistance in clinic for prevention and control of infection effectively.

关 键 词：病原菌 耐药性 抗菌药物 监测 

分 类 号：R378[医药卫生—病原生物学]