左卡尼汀治疗慢性肾衰合并冠心病/心律失常的疗效及对患者氧化低密度脂蛋白的影响  

Clinical Efficacy of Levocarnitine for Patients with Chronic Renal Failure Complicated with Coronary Heart Disease / Arrhythmia and its Influence on Oxidized Low Density Lipoprotein

作　　者：王茜[1] 沈红 

机构地区：[1]台州市立医院血透科,浙江台州318000 [2]台州恩泽医疗中心(集团)临海医院肾内科

出　　处：《药物流行病学杂志》2015年第4期203-206,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:观察左卡尼汀治疗慢性肾衰合并冠心病/心律失常的临床疗效及其对患者氧化低密度脂蛋白(oxLDL)的影响。方法:64例慢性肾衰合并冠心病心律失常患者按入院先后顺序分为对照组和观察组各32例。对照组接受血液透析及内科常规治疗,观察组在对照组基础上加用左卡尼汀。3个月疗程结束后,比较两组患者的临床疗效,以及治疗前后左心室舒张末期内径(LVDD)、左室收缩末期内径(LVSD)、左心室射血分数(LVEF)、左室短轴缩短率(LVSF)等心功能指标和血清ox-LDL水平等治疗前后的变化。结果:两组患者治疗后各项心功能指标均较治疗前有明显改善(P<0.05),且观察组改善幅度明显大于对照组(P<0.05);治疗后观察组ox-LDL水平较治疗前明显下降(P<0.05),且显著低于对照组(P<0.05)。观察组冠心病和心律失常临床总有效率均显著高于对照组(P<0.05)。结论:左卡尼汀联合常规治疗可明显改善患者心功能,降低慢性肾衰合并冠心病患者心律失常及心绞痛的发作频率,有效降低血清ox-LDL水平。Objective： To observe the clinical efficacy of levocarnitine on chronic renal failure complicated with coronary heart disease / arrhythmia,and its influence on oxidized low density lipoprotein（ ox-LDL） concentration of the patients. Methods： 64 cases of patients with chronic renal failure complicated with coronary heart disease / arrhythmia were randomly divided into control group and observation group,each group had 32 cases. The control group received hemodialysis and routine treatment,the observation group were treated by levocarnitine based on the control group,the two groups were treated for 3 months,the clinical effect,left ventricular diastolicdiameter（ LVDD）. left ventricular end systolic diameter（ LVSD）,left ventricular ejection fraction（ LVEF）,left ventricular fractional shortening（ LVSF）,serum ox-LDL concentration before and after the treatment was compared between two groups. Results： After 3 months of treatment,the cardiac function of two groups patients was significantly improved（ P〈0. 05）,and the observation group improved more significantly than before（ P〈0. 05） and the control group（ P〈0. 05）. After treatment,the level of ox-LDL of the observation group was significantly lower than the control group（ P〈0. 05）. The total clinical effective rate of the observation group were significantly higher than that of the control group（ P〈0. 05）. Conclusion： Levocarnitine combined with routine treatment can significantly improve cardiac function,reduced the frequency of chronic renal failure complicated with cardiac arrhythmia in patients with coronary heart disease and angina attack,but also can effectively reduce the level of serum oxLDL.

关 键 词：慢性肾功能衰竭 心律失常 左卡尼汀 氧化低密度脂蛋白 

分 类 号：R977[医药卫生—药品]