新型人工机械心脏瓣膜材料表面制备氧化钛薄膜  

Preparation of Ti-O Film Deposited on the Surface of a New Type of Artificial Mechanical Heart Valve

作　　者：周丰[1] 崔园园[1] 武亮亮[1] 孙鸿[1] 黄楠[1] 

机构地区：[1]西南交通大学材料先进技术教育部重点实验室材料科学与工程学院,成都610031

出　　处：《生物医学工程学杂志》2015年第2期430-433,共4页Journal of Biomedical Engineering

摘　　要：通过真空磁过滤高弧源沉积溅射技术,制备纯钛TA2(纯度99.999%)材料表面沉积金红石结构的氧化钛(Ti-O)薄膜,能不降低基体材料本身机械力学性能,改善钛基植入器械表面性能,获得使用性能更佳的生物相容性材料,为人工心脏瓣膜提供更能适应体内生理环境的植入材料。文中在人工机械心脏瓣膜表面制备Ti-O薄膜以获得更佳的使用性能。薄膜制备过程首先使用Ar离子溅射清洗材料表面,去除材料表面多余的杂质,然后利用金属离子源激发产生的Ti离子同射频放电产生的氧离子,在强磁场弯管的引导下,加速撞击在工作台上施加一定负偏压的样件,对TA2材料表面及Si(100)表面(参照样)沉积Ti-O薄膜,在真空室内一定氧分压条件下,得到成分、结构一定的Ti-O薄膜。通过X射线衍射实验分析材料表面结构与成分,确定在氧分压为0.18Pa时在材料表面获得的金红石型Ti-O薄膜晶体;纳米划痕实验检测薄基结合力结果表明,薄膜与基体结合力强;水接触角表征及血小板凝血实验结果证实材料表面改性后的Ti-O薄膜具有更优的抗血小板黏附能力。通过这些评价说明改性后的金红石类Ti-O薄膜材料,薄膜与基底结合良好,具有好的抗凝效果,可供人工机械心脏瓣膜等植入器械材料选择使用。The rutile structure titanium oxide（Ti-O）film was prepared on the pure titanium material TA2（99.999%）surface by the magnetic filter high vacuum arc deposition sputtering source.The method can not only maintain the material mechanical properties,but also improve the surface properties for better biocompatibility to accommodate the physiological environment.The preparation process of the Ti-O film was as follows.Firstly,argon ions sputtered to the TA2 substrate surface to remove the excess impurities.Secondly,a metal ion source generated Ti ions and oxygen ions by the RF discharge.Meanwhile a certain negative bias was imposed on the sample.There a certain composition of Ti-O film was obtained under a certain pressure of oxygen in the vacuum chamber.Finally,Xray diffraction was used to research the structure and composition of the film.The results showed that the Ti-O film of the rutile crystal structure was formed under the 0.18 Pa oxygen partial pressure.A Nano scratch experiment was used to test the coating adhesion property,which demonstrated that the film was stable and durable.The contact angle experiment and the platelet clotting experiment proved that the modified surface method had improved platelet adhesion performance,and,therefore,the material possessed better biocompatibility.On the whole,the evaluations proved the modified material had excellent performance.

关 键 词：氧化钛 表面改性 金属弧源沉积 

分 类 号：R318.11[医药卫生—生物医学工程]