共济失调毛细血管扩张症突变基因与心血管疾病危险因素的研究进展  

Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease

作　　者：丁香[1] 丁义[2] 岳冀蓉[1] 肖恒怡[2] 董碧蓉[1] 

机构地区：[1]四川大学华西医院老年干部科,成都610041 [2]四川大学生物治疗国家重点实验室老年医学研究室,成都610041

出　　处：《生物医学工程学杂志》2015年第2期475-479,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81100148);国家教育部博士学科点专项科研基金资助项目(20100181110026);四川省科技厅支撑计划资助项目(2010SZ0181)

摘　　要：心血管疾病是一种严重威胁人类健康和生命的疾病,导致其发病的因素很多,其中遗传方面的因素近年来受到高度重视。大量研究表明,共济失调毛细血管扩张症突变(ATM)基因若发生缺失或突变,会导致DNA损伤修复缺陷、端粒缩短、抗氧化能力下降、胰岛素抵抗、血脂水平增高等,进而导致衰老、动脉粥样硬化及代谢综合征等心血管疾病危险因素的发生。本文就ATM基因与心血管疾病危险因素之间的作用机制进行综述,以期为相关基础研究和临床应用提供一定的参考依据。Cardiovascular disease is a severe threat to human health and life.Among many risk factors of cardiovascular disease,genetic or gene-based ones are drawing more and more attention in recent years.Accumulated evidence has demonstrated that the loss or mutation of ataxia telangiectasia mutated（ATM）gene can result in DNA damage repair dysfunctions,telomere shortening,decreased antioxidant capacity,insulin resistance,increased lipid levels,etc.,and thus can promote the occurrence of cardiovascular risk factors,such as aging,atherosclerosis and metabolic syndrome.In this review,we discusses the possible mechanisms between ATM gene and cardiovascular risk factors,which could be helpful to the related research and clinical application.

关 键 词：共济失调毛细血管扩张症突变基因 衰老 动脉粥样硬化 代谢综合征 DNA损伤 

分 类 号：R54[医药卫生—心血管疾病]