应用小剂量索利那新治疗小儿遗尿症的体会  

Effect of small dose solifenacin in the treatment of pediatric primary nocturnal enuresis

作　　者：黎灿强[1] 邱敏捷[1] 徐乐[1] 

机构地区：[1]南方医科大学附属何贤纪念医院泌尿外科,广州511400

出　　处：《天津医药》2015年第4期436-438,共3页Tianjin Medical Journal

摘　　要：目的探讨小剂量索利那新治疗小儿原发性夜间遗尿症的临床价值。方法 78例原发性夜间遗尿症患儿随机分为治疗组和对照组(各39例)。2组患儿均接受行为干预治疗,治疗组同时给予索利那新(5 mg/片,1/3片,每天1次)。2组均治疗3个月并随访3个月,记录2组患儿的疗效及复发率。结果疗程结束时和随访3个月治疗组有效率均高于对照组(89.7%vs 69.2%,82.1%vs 46.2%,均P<0.05)。随访观察3个月,治疗组复发率低于对照组(8.6%vs 33.3%,P<0.05)。结论小剂量索利那新治疗小儿遗尿症安全、有效,配合行为干预治疗可提高疗效,减少复发。Objective To evaluate the clinical value of small doses of solifenacin to treat children of primary nocturnal enuresis. Methods Children （n=78） of primary nocturnal enuresis were randomly divided into treatment group（39 cases） and control group（39 cases）. All children received behavioral intervention therapy, while children in the treatment group were given Solifenacin（5 mg/tablet, 1/3 tablet, 1 times a day for 3 months） orally besides behavioral therapy. Children were followed up for 3 months after the end of the treatment, and the curative effect and recurrence rate were compared between two groups. Results Compared with that of children in control group, cure rate of children in treatment group is higher at the end of treatment （89.7%vs 69.2%, P〈0.05） as well as by 3 month of follow-up time （82.1%vs 46.2%, P＆lt;0.05）. The re？currence rate of children in treatment group, by three months follow-up time, was lower than that of children in control group （8.6%vs 33.3%,P〈0.05）. Conclusion Small dose of Solifenacin in addition to behavioral intervention is safe and effec？tive in treatment of children with enuresis, which enhance cure rate and reduce recurrence.

关 键 词：夜遗尿症 治疗结果 儿童 索利那新 行为干预 复发率 

分 类 号：R726.945.3[医药卫生—儿科]