高密度脂蛋白:影响血管内皮功能的双刃剑  

High density lipoprotein: the double-edge sword on endothelial function

作　　者：赵莉莉[1] 毛用敏[1] 

机构地区：[1]天津市心血管病研究所,天津市胸科医院,300222

出　　处：《天津医药》2015年第4期439-442,共4页Tianjin Medical Journal

基　　金：天津市卫生局科技基金项目(2013KY35)

摘　　要：在动脉粥样硬化病变的初始阶段,许多致动脉粥样硬化因素可损伤血管内皮,诱发内皮功能紊乱,内皮功能紊乱是动脉粥样硬化发病的重要机制。高密度脂蛋白(HDL)是由多种蛋白和脂质组成的功能复杂的脂蛋白。流行病学研究显示HDL与动脉粥样硬化呈负相关。HDL除参与胆固醇逆向转运、减少外周胆固醇堆积、防止泡沫细胞形成功能外,还可通过调节血管舒张功能、发挥抗氧化抗炎作用保护内皮功能,对抗动脉粥样硬化形成。但在冠心病患者体内存在失功能性HDL,其可能诱发内皮功能紊乱。本文就功能性HDL和失功能性HDL与内皮功能的关系进行综述。Chronic exposure to risk factors at the beginning stage of atherosclerosis development can damage endotheli？um and ultimately initiat endothelial dysfunction. Endothelial dysfunction is one of the major mechanisms in atherosclerosis development. High-density lipoprotein （HDL） is a lipoprotein with complicated function and is composed of a variety of pro？teins and lipids. Epidemiological studies showed an inverse correlation between HDL and atherosclerosis. The protective role of HDL on endothelium might related to its function in reversing cholesterol transport, reducing peripheral cholesterol accu？mulation, preventing foam cells formation, dilating vessels, antioxidant and anti-inflammation, all of which antagonize devel？opment of atherosclerosis. But HDL obtained from patients with cardiovascular disease which has known dysfunctional HDL may induce endothelial dysfunction. This review addresses the relationships between functional HDL or dysfunctional HDL with the endothelial function.

关 键 词：动脉粥样硬化 内皮 血管 脂蛋白类 HDL 功能性HDL 失功能性HDL 

分 类 号：R541.4[医药卫生—心血管疾病]