急性有机磷农药中毒早期血药浓度与Fas/FasL表达关系的临床研究  

Clinical study on the relationship between the expression of Fas/FasL,blood drug concentration and early acute organic phosphorus pesticide poisoning

作　　者：杨伟红[1] 彭广军[1] 梁璐[1] 王新平[1] 

机构地区：[1]河北大学附属医院急诊医学科,河北保定071000

出　　处：《热带医学杂志》2015年第3期348-350,共3页Journal of Tropical Medicine

基　　金：保定市科学技术研究与发展指导计划(12ZF080)

摘　　要：目的分析急性甲胺磷农药中毒早期血药浓度与T淋巴细胞亚群的关系及其临床意义。方法选取2007年1月至2013年6月河北大学附属医院急诊医学科收治的急性甲胺磷农药中毒患者92例,按中毒严重程度分为轻中度中毒组(n=54)和重度中毒组(n=38),选取92例健康体检者作为对照组,测定Fas、Fas L以及有机磷农药含量。结果重度中毒组血药浓度为(2.13±0.32)μmol/L,明显高于轻中度中毒组的(1.35±0.18)μmol/L,差异有统计学意义(P<0.01)。Fas/Fas L表达重度中毒组明显高于轻中度中毒组和对照组,差异有统计学意义(P<0.01);轻中度中毒组亦高于对照组,差异有统计学意义(P<0.01)。结论急性甲胺磷农药中毒早期血药浓度越高,中毒程度愈重,细胞凋亡越严重。Objective To analyze acute methamidophos poisoning early blood drug concentration and T lymphocyte subsets and its clinical significance. Methods 92 cases of acute methamidophos poisoning were divided into mild to moderate poisoning group 54 cases and severe poisoning group 38 cases;another 92 healthy subjects served as control group. The relationship between the blood drug concentration and Fas / FasL of 2 groups was analyzed. Results Serum drug concentration of severe poisoning group was significantly higher than that in mild to moderate poisoning group（P 〈0.01）. The expression of Fas / FasL in severe poisoning group was significantly higher than that in mild to moderate poisoning group（P〈0.01）. Conclusion For acute methamidophos pesticide poisoning,the degree of poisoning and cell apoptosis were related to the early blood drug concentration.

关 键 词：甲胺磷 血药浓度 FAS/FAS L 

分 类 号：R139.3[医药卫生—劳动卫生]