绝经后骨质疏松症的T细胞亚群的变化及意义  

Change and Significance of T Cell Subsets in Postmenopausal Women with Osteoporosis

作　　者：徐玉善[1] 江艳[1] 李少遊 李红[1] 洪敏[2] 李文艳[1] 包秋燕[1] 

机构地区：[1]昆明医科大学第一附属医院内分泌代谢病科,云南昆明650032 [2]昆明医科大学第一附属医院肿瘤内科,云南昆明650032

出　　处：《昆明医科大学学报》2015年第4期34-36,共3页Journal of Kunming Medical University

基　　金：云南省卫生厅卫生科技计划项目(2007C009Z;2012ws0031)

摘　　要：目的探讨绝经后骨质疏松症女性患者外周血的T细胞亚群的改变及意义.方法流式细胞仪检测68例绝经后骨质疏松症女性及60例无骨质疏松症绝经后女性外周血的T细胞亚群,绝经后骨质疏松症女性患者外周血的T细胞亚群的改变.结果绝经后骨质疏松症女性患者外周血的T抑制/毒性淋巴细胞(Ts)比率降低,Th/Ts比值升高,NK细胞、B淋巴细胞升高(P<0.05).结论外周血的T淋巴细胞亚群的变化可能促进了OP的发生发展.NK细胞、B淋巴细胞在体液免疫、免疫应答当中也出现相应的改变,进一步加重了绝经期妇女的免疫紊乱.Objective To investigate the change and significance of peripheral blood T cell subsets in postmenopausal women with osteoporosis. Methods Peripheral blood T cell subsets in postmenopausal women with osteoporosis （n =68） and postmenopausal women without osteoporosis （n =60） subjects were detected by flow cytometry. Results The ratio of peripheral blood T suppressor/cytotoxic lymphocytes （Ts） was decreased, while Th/Ts ratio, NK cells and B lymphocytes levels were increased in postmenopausal women with osteoporosis. Conclusion Changes in peripheral blood T lymphocyte subsets may promote the development of the osteoporosis. NK cells and B lymphocytes in humoral immune response are also changed, which can further exacerbate the immune disorder of menopausal women.

关 键 词：T细胞类别 CD4^+Th细胞 绝经 骨质疏松症 

分 类 号：R392.12[医药卫生—免疫学]