呼出气一氧化氮浓度在婴幼儿喘息性疾病中的意义  

The significance of exhaled nitric oxide concentration in infants and young children with asthmatic diseases

作　　者：曾彩霞[1] 孙中厚[1] 安百梅[1] 郑晓静[1] 武帆[1] 

机构地区：[1]潍坊医学院,山东潍坊261031

出　　处：《现代医药卫生》2015年第8期1127-1130,共4页Journal of Modern Medicine & Health

摘　　要：目的通过探讨呼出气一氧化氮（Fe NO）水平、分泌型免疫球蛋白E（s Ig E）、外周血嗜酸性粒细胞（EOS）和第1秒用力肺活量占预计值百分比（FEV1%）的相关性,以观察婴幼儿喘息患儿是否存在肺通气功能障碍和气道慢性炎性反应,以期深入了解婴幼儿喘息与哮喘之间的相关性。方法选择2014年1-10月该院儿科病房住院的年龄4-5岁同期住院确诊为婴幼儿喘息患儿共123例,其中确诊为婴幼儿哮喘的82例为哮喘组,支气管肺炎41例为肺炎组,另选择择期手术患儿40例为对照组。对哮喘组再分为急性期（治疗前）、缓解期（治疗12周后）,分别测定各组Fe NO、EOS、s Ig E及FEV1%水平,并进行统计学分析。结果 （1）哮喘组急性期Fe NO[（55.42±6.12）×10-9 mmol/L]、EOS[（2.48±0.41）×109 L-1]、s Ig E[（17.25±0.93）U/m L]分别高于哮喘组缓解期[（22.33±1.29）×10-9 mmol/L、（0.61±0.12）×109 L-1、（1.45±0.61）U/m L]、肺炎组[（10.76±0.49）×10-9mmol/L、（0.09±0.05）×109L-1、（0.14±0.17）U/m L]和对照组[（10.74±0.46）×10-9mmol/L、（0.09±0.07）×109L-1、（0.17±0.11）U/m L];FEV1%[（70.41±2.91）%]低于哮喘组缓解期[（91.30±1.84）%]、肺炎组[（90.66±1.25）%]和对照组[（92.08±1.05）%],差异均有统计学意义（P〈0.05）。（2）哮喘组缓解期Fe NO、EOS水平及s Ig E仍高于肺炎组,差异均有统计学意义（P〈0.05）;而两组FEV1%比较,差异无统计学意义（P〉0.05）。（3）哮喘组缓解期Fe NO、EOS水平及s Ig E仍高于对照组,差异均有统计学意义（P〈0.05）,而两组FEV1%比较,差异无统计学意义（P〉0.05）。（4）肺炎组Fe NO、EOS、s Ig E及FEV1%与对照组比较,差异无统计学意义（P〉0.05）。（5）哮喘患儿Fe NO水平与EOS、s Ig E呈正相关（r=0.71,P〈0.05）,Fe NO水平与FEV1%、EOS与FEV1%、s Ig E与FEV1%均无明显相关性（r=-0.14、-0.06、-0.09,P〉0.05）。结论哮喘患儿的Fe Objective To observe whether the children patients exist lung ventilation dysfunction and chronic airway in-flammation and investigate the correlation between the infant asthma and asthma by fractional exhaled nitric oxide（Fe NO） concentrations,secretory immanoglobulin E（s Ig E）,peripheral blood eosinophils（EOS） and pulmonary function test（FEV1%）. Methods A total of 123 children patients confirmed as infant asthma aged 4-5 years old in the ward of department of pediatrics of this hospital from January to October in 2014 were selected including the asthma group with 82 cases diagnosed as infant asthma, the pneumonia group with 41 cases as bronchial pneumonia and the control group with 40 healthy cases,in which,the asthma group was divided into the acute stage（before the treatment）,the remission stage（after the treatment for 12 weeks）. Fe NO,EOS,s Ig E and FEV1% of each group were measured finally and then the figures were statistically analyzed. Results（1）Fe NO（55.42 ±6.12）×10-9mmol/L,EOS（2.48±0.41）×109L-1,s Ig E（17.25±0.93）U/m L of the asthma group in the acute period were higher than those of the remission period[（22.33±1.29）×10-9mmol/L,（0.61±0.12）×109L-1,（1.45±0.61）U/m L,the pneumonia group[（10.76±0.49）×10-9mmol/L,（0.09±0.05）×109L-1,（0.14±0.17）U/m L] and the control group[（10.74±0.46）×10-9mmol/L,（0.09±0.07）×109L-1,（0.17±0.11）U/m L]. FEV1% level（70.41±2.91）% was lower than the remission group（91.30±1.84）%,the pneumonia group（90.66±1.25）% and the control group（92.08±1.05）%,all of which had statistical significance in difference（P〈0.05）.（2）Fe NO,EOS and s Ig E levels of the asthma group at the remission stage were still higher than those of the pneumonia group,and the difference had statistical significance（P〈0.05）. But the difference of FEV1% concentration between the two groups was not statistically significant（P〈0.05）.（3）Fe NO,EOS and s Ig E levels of the asthma group at

关 键 词：哮喘 肺炎 一氧化氮 嗜酸细胞 变应原 呼吸功能试验 儿童 

分 类 号：R562.2[医药卫生—呼吸系统]