45S5生物活性玻璃仿生矿化酸蚀的牙釉质的研究  

Study of bionic mineralization of acidic enamel with 45S5 bioactive glass

作　　者：董志红[1] 周长春[2] 聂志萍[1] 

机构地区：[1]成都大学材料系,成都610106 [2]四川大学国家生物医学工程研究中心,成都610064

出　　处：《高技术通讯》2015年第1期97-101,共5页Chinese High Technology Letters

基　　金：国家自然科学基金(No.81201475)资助项目

摘　　要：采用45S5生物活性玻璃对酸蚀的牙釉质进行了仿生矿化处理，旨在诱导牙釉质在模拟人工唾液环境中的再矿化衍0用激光粒度分析仪、X-射线衍射仪（XRD）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）、原子力显微镜（AFM）及纳米压痕（nanoindentation）技术对矿化层及牙釉质基体进行了对比研究。结果表明：一定粒径尺寸范围内（1～10μm）的45S5生物玻璃可粘附在牙釉质表面，在模拟口腔唾液环境中浸泡7天后，可形成一层矿化层，结构类似于牙釉质的类骨磷灰石，厚约0．8～1．2μm，且力学性能和表面粗糙度都优于酸蚀的牙釉质。45S5作为诱导矿化的仿生材料，可保护牙齿及预防龋齿发生。Acidic etched enamel was treated with the 45S5 bioactive glass to induce the enamel＇ s mineralization in the simulated oral fluid （SOF）. The comparative analysis of the samples of mineralized layer and base enamel was con- ducted by using the techniques of laser particle size analyzer, X-ray diffractometry （XRD）, scanning electron mi- croscopy （ SEM）, transmission electron microscopy （TEM）, atomic force microscopy （AFM） and nanoindenta- tion. The results indicated that a range size of 45S5 particles （1 ～ 10μm） were adhered onto the acidic etched en- amel surface, and when soaked in the SOF for 7 days, a mineralized layer was formed. The layer＇ s structure was similar to apatite, and its thickness was about 0.8 ～ 1.2μm, and its mechanical properties and surface roughness were superior to that of etched enamel. The 45S5 bioaetive glass can be used as a bionic mineralization material to protect teeth from dental caries.

关 键 词：牙釉质 45S5生物活性玻璃 再矿化 

分 类 号：TQ171.1[化学工程—玻璃工业]