保元汤提取物对“阳虚”小鼠的免疫药理作用(英文)  

Immunopharmacological effects of extract of Baoyuantangon mice with deficiency of vital function

作　　者：宋春华[1] 檀碧华[2] 胡永良[3] 宋建国[4] 吴敏毓[1] 

机构地区：[1]皖南医学院微生物与免疫教研室,芜湖241001 [2]皖南医学院弋矶山医院,芜湖241001 [3]皖南医学院生理学教研室,芜湖241001 [4]皖南医学院药理学教研室,芜湖241001

出　　处：《中国临床药理学与治疗学杂志》1998年第1期18-21,共4页

摘　　要：目的研究保元汤提取物对“阳虚”小鼠的免疫药理作用。方法用氢化可的松制备“阳虚”模型 ;巨噬细胞吞噬作用和C3b受体的检测分别用MTT法和YC花环形成实验 ;T淋巴细胞转化实验用MTT掺入法。结果保元汤提取物给“阳虚”小鼠灌胃给药二周后 ,观察其免疫药理作用 ,结果发现 ,两个剂量组皆能阻止“阳虚”小鼠体重、WBC、胸腺重和胸腺指数,以及脾重和脾指数的降低 ,尤以大剂量组(IDA组)明显。并且具有恢复其T细胞转化率和巨噬细胞吞噬率和YC花环形成率的作用。结论保元汤提取物具有拮抗“阳虚”Aim The immunopharmalogical roles of extract of Baoyuantang in mice with deficiency of vital function (DVF) were studied.Methods The mouse model with DVF was prepared by i.m administration of hydrocortisomum. Detection of phagocytosis and C3b receptor of macrophage was carried out with MTT method and YC rosette forming assay respectively. T cell transformation assay was carried out with the method of MTT incorporation. The body weigh ,idexes of spleen and thymus and WBC of the mice were determined by routine.Reaults The extract of Baoyuantang could block the decrease of body weight, WBC and the weight and index of thymus and spleen, and recover the function of T cells and macrophage in mice with DVF.Conclusion The extract of Baoyuantang had a supplementary treatmental effects on mice with DVF caused by hydrocortisonum.

关 键 词：保元汤 提取物 “阳虚” 小鼠 免疫药理作用 

分 类 号：R285.5[医药卫生—中药学]