帕瑞昔布对人结肠癌SW1116细胞裸鼠移植瘤生长的影响及安全性观察  

Security observation and antitumor effect of parecoxib in a xenograft model of human colon cancer SW1116 cells

作　　者：杨海波[1] 马艳春[1] 赵成根[1] 王建东[1] 高家治[1] 施展[1] 

机构地区：[1]上海中医药大学附属普陀医院肛肠外科,上海200062

出　　处：《中南药学》2015年第3期238-241,共4页Central South Pharmacy

基　　金：上海市教委基金资助项目(No.2012JW66);上海市普陀区卫生系统自主创新科研基金(No.22012PTKW008)

摘　　要：目的观察帕瑞昔布对人结肠癌SW1116细胞裸鼠皮下移植瘤生长的抑制作用及安全性。方法建立人结肠癌SW1116细胞裸鼠皮下移植瘤模型。将24只BALB/C裸鼠随机分为对照组、帕瑞昔布组和5-Fu组。记录各组裸鼠的体重和瘤体积变化,用药30 d后取瘤及脾脏,计算脾脏指数、抑瘤率,检测血清ALT和BUN,并用透射电镜观察瘤组织的形态学变化。结果帕瑞昔布组未见明显的药物相关毒副反应。帕瑞昔布能抑制SW11 16细胞裸鼠皮下移植瘤的生长。在干预前18 d,帕瑞昔布组的肿瘤抑制率逐渐增加,但随着药物干预时间的延长,抑制率却逐渐降低。结论裸鼠体内短期应用帕瑞昔布（15~18 d）是安全的,并能抑制SW1116细胞皮下移植瘤的生长。Objective To observe the security and antitumor effect of parecoxib in a xenograft model of human colon cancer SW1116 cells. Methods Xenograft mouse models were established by injecting human colon cancer SW1116 cells into the BALB/C nude mice subcutaneously. Twenty four mice were randomly divided into 3 groups： a control group, a parecoxib group and a 5-Fu group. The body weight and tumor volumes were measured every 3days. After 30 days treatment, the spleen index, tumor inhabitory rate and serum leveles of ALT and BUN were determined. The morphological features of tumor tissues were observed under transmission electron microscope. Results Parecoxib group was well tolerated without obvious signs of drug-related toxicity throughout this study. Parecoxib inhibited xenograft tumor growth of SW1116 cells in nude mice. The tumor inhibitory rate in the parecoxib group increased before day 18, but gradually decreased later. Conclusion Parecoxib can suppress xenograft tumor growth, and shortterm treatment（15- 18 d） is safe in nude mice.

关 键 词：帕瑞昔布 人结肠癌SW1116细胞 裸鼠 皮下移植瘤 安全性 

分 类 号：R965[医药卫生—药理学] R979.1[医药卫生—药学]