太白银莲花地上部分化学成分的研究  

Chemical constituents from the aerial parts of Amenone taipaiensis

作　　者：李慧[1] 汤海峰[1,2] 王啸洋[3] 王夏茵 华栋[2] 刘杨[2] 

机构地区：[1]陕西中医学院,陕西咸阳712046 [2]第四军医大学天然药物化学教研室,西安710032 [3]中国人民解放军302医院药学部,北京100039

出　　处：《中南药学》2015年第3期263-266,共4页Central South Pharmacy

基　　金：国家自然科学基金(No.81274029);陕西省科技统筹创新工程计划资源主导型产业关键技术(链)项目(No.2013KTCL03-10);陕西省中医管理局中医药科学技术研究重点课题(No.ZY36)

摘　　要：目的对太白银莲花地上部分化学成分进行研究。方法样品用70%的乙醇进行提取,所得浸膏用水分散后,经石油醚和正丁醇依次进行萃取,将所得的正丁醇层经正相硅胶、Sephadex LH-20、反相硅胶(RPC18)、高效液相制备等多种色谱方法分离得到单体化合物,根据其理化性质及波谱学数据鉴定其化学结构。结果分离得到5个单体化合物,分别被鉴定为白头翁皂苷D(1)、红毛七皂苷D(2)、3β-O-(α-Larabinopyr-anosyl)oleanolic acid(3)、leontoside(4)、β-胡萝卜苷(5)。结论 5个化合物均为首次从该植物的地上部分分离得到。Objective To determine the chemical constituents from the aerial parts of Amenone taipaiensis. MethodsThe air-dried aerial parts of Amenone taipaiensis（5.5 kg） were extracted with 70% Et OH, and the residue was suspended in H2 O and extracted with petroleum ether and N-butanol, respectively. Column chromatographies（including silica gel, Sephadex LH-20 and ODS） and preparative HPLC were used to separate the monomer compounds and the structures were elucidated by spectroscopic data. Results Totally 5 compounds were separated and identified as nicotinamide pulsatilla saponin D（1）, cauloside D（2）, 3β-O-（α-L-arabinopyranosyl） oleanolic acid（3）, leontoside（4）, and β-daucosterol（5）. Conclusion Five compounds have been isolated from the aerial parts of this plant for the first time.

关 键 词：太白银莲花 地上部分 化学成分 

分 类 号：R284.2[医药卫生—中药学]