替硝唑栓剂溶出度测定方法改进研究  

Improvment for dissolution determination of tinidazole suppository

作　　者：李正刚[1,2] 赵先辉 陈大为[1] 

机构地区：[1]沈阳药科大学,沈阳110016 [2]吉林一正药业集团有限公司,吉林四平136001

出　　处：《中南药学》2015年第3期277-279,共3页Central South Pharmacy

摘　　要：目的建立测定替硝唑栓剂溶出度的试验法,提供药品评价和质量控制的依据。方法采用比色法,利用渗透袋装置,以1 000 m L水为溶出介质。结果替硝唑栓剂5 h溶出度>85%。结论此方法准确、快速、简便。为控制替硝唑栓剂的质量提供了一种有效的溶出度测定方法。Objective To establish a method to determine the dissolution of tinidazole suppository and provide a basis for drug appraisal and quality control. Methods The dissolution rate was determined by colorimetry with the penetration dissolution instrument and 1 000 m L water（p H 5- 7） as the dissolution medium. Results The dissolution of tinidazole suppository after 5 h was above 85%. Conclusion The method is simple, rapid and accurate.

关 键 词：替硝唑 栓剂 溶出度 

分 类 号：R943[医药卫生—药剂学]