褐藻氨酸对肾性高血压大鼠的降压作用  

Hypotensive effect of laminine in renal hypertensive rats

作　　者：臧东莲[1] 徐庆荣 王蕾[1] 孙世锡[1] 

机构地区：[1]青岛医学院药理教研室,青岛266021

出　　处：《中国临床药理学与治疗学杂志》1998年第1期24-25,共2页

摘　　要：目的探讨褐藻氨酸的降压作用。方法用肾外包扎法使大鼠形成肾性高血压模型。模型组分为高剂量组(300μg/kg) ,低剂量组(150mg/kg) ,并设阳性对照组和阴性对照组 ,均行灌胃 ,每天1次 ,共20天。结果低剂量组大鼠血压降低20 2 % ,高剂量组降低26 2 % ,与生理盐水组比较均有非常显著性差异(P<0.01)。Aim The antihypertensive effect of laminine was studied in renal hypertensive rat models.Methods The left kidney was wrapped by nylon fabrics and the right kidney was removed under anesthesia to set up the hypertensive rat model.The systolic blood pressure was measured by the tail method. Laminine 150 and 300 mg/(kg·d) were given orally to hypertensive rats in low dose group and high dose group respectively for 20 days, and nifendipine 10 mg/kg·d as positive control, NS as negative control. The hypotensive effects were observed on the third and seventh day after the administration of laminine. Results After 20 days, the systolic blood pressure of rats was lowered by 20.2% in low dose group 20.2% and by 26.4% in high dose group respectively, in comparison with negative control, there were significant differences (P<0.01).Conclusion The results showed that laminine had hypotensive effects.

关 键 词：褐藻氨酸 肾性高血压 大鼠 降压作用 

分 类 号：R972.4[医药卫生—药品] R544.14[医药卫生—药学]