肾脏组织冷灌注过程的物性参数研究  

Analysis of Physical Parameters of Kidney Tissues during Cold Perfusion Processes

作　　者：张密[1] 诸凯[1] 梁飞[1] 王雅博[1] 安娜[1] 

机构地区：[1]天津商业大学天津市制冷技术重点实验室,天津300134

出　　处：《高校化学工程学报》2015年第2期253-258,共6页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金(51076117)

摘　　要：目前许多学者致力于研究低温保存过程中生物组织材料的力学性能。在冷灌注过程中,内部温度的不均匀导致组织产生热应力,对生物组织造成损伤。为了更好地了解这一现象,研究重点定量考察温度与线性热膨胀系数和杨氏模量的关系,并应用一种新的方法测量肾脏组织在降温过程中产生的热应变。这种方法是利用低温显微系统获取不同降温速率下的肾脏组织图像,然后应用Vic-2D软件分析肾脏组织在特定温度和参照温度下所拍图像之间的微小形变,从而获得热应变数值。而杨氏模量是利用静态拉伸法测定不同温度下组织应力及应变,拟合出其杨氏模量数值。实验结果显示在0~20℃内,线性热膨胀系数是随着温度的降低而升高的;而杨氏模量在这个温度范围内保持恒定。Many researchers studied mechanical behaviors of biological materials during cryopreservation processes, as inhomogeneous internal temperature fields during cold perfusion may cause thermal stress. This study aims to quantify and explain the temperature dependence of linear thermal expansion coefficient and Young＇s modulus. A new method for thermal strain measurements of kidney tissue during cooling process was presented. In order to calculate thermal strain during cooling, cryomicroscopy was used to obtain images at different cooling rates. Vic-2D software was used to analyze the tiny displacement between the image at specified temperature and the reference. The stress and strain obtained by the static tension method was used to fit the Young＇s modulus at different low temperatures. The results show that the linear thermal expansion coefficient increases as the temperature decreases from 20℃ to 0℃ and the Young＇s Modulus keeps constant at this temperature range.

关 键 词：生物组织 热应力 线性热膨胀系数 杨氏模量 

分 类 号：TK124[动力工程及工程热物理—工程热物理]